Oncolytic polio virotherapy of cancer

Michael C. Brown, Elena Y. Dobrikova, Mikhail I. Dobrikov, Ross W. Walton, Sarah L. Gemberling, Smita K. Nair, Annick Desjardins, John H. Sampson, Henry S. Friedman, Allan H. Friedman, Douglas S. Tyler, Darell D. Bigner, Matthias Gromeier

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

Recently, the century-old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several late-stage clinical trials in a variety of cancers. Although originally prized for their direct tumor cytotoxicity (oncolytic virotherapy), recently, the proinflammatory and immunogenic effects of viral tumor infection (oncolytic immunotherapy) have come into focus. Indeed, a capacity for eliciting broad, sustained antineoplastic effects stemming from combined direct viral cytotoxicity, innate antiviral activation, stromal proinflammatory stimulation, and recruitment of adaptive immune effector responses is the greatest asset of oncolytic viruses. However, it also is the source for enormous mechanistic complexity that must be considered for successful clinical translation. Because of fundamentally different relationships with their hosts (malignant or not), diverse replication strategies, and distinct modes of tumor cytotoxicity/killing, oncolytic viruses should not be referred to collectively. These agents must be evaluated based on their individual merits. In this review, the authors highlight key mechanistic principles of cancer treatment with the polio:rhinovirus chimera PVSRIPO and their implications for oncolytic immunotherapy in the clinic.

Original languageEnglish (US)
Pages (from-to)3277-3286
Number of pages10
JournalCancer
Volume120
Issue number21
DOIs
StatePublished - Nov 1 2014

Keywords

  • CD155
  • eIF4G
  • innate antiviral response
  • interferon
  • internal ribosomal entry site
  • nectin-like molecule 5
  • oncolytic virus
  • poliovirus
  • translation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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