One more piece in the VACV ecological puzzle: Could peridomestic rodents be the link between wildlife and bovine vaccinia outbreaks in Brazil?

Jônatas S. Abrahão, Maria Isabel M. Guedes, Giliane S. Trindade, Flávio G. Fonseca, Rafael Kroon Campos, Bruno F. Mota, Zélia I.P. Lobato, André T. Silva-Fernandes, Gisele O.L. Rodrigues, Larissa S. Lima, Paulo C.P. Ferreira, Cláudio A. Bonjardim, Erna G. Kroon

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Abstract

Background: Despite the fact that smallpox eradication was declared by the World Health Organization (WHO) in 1980, other poxviruses have emerged and re-emerged, with significant public health and economic impacts. Vaccinia virus (VACV), a poxvirus used during the WHO smallpox vaccination campaign, has been involved in zoonotic infections in Brazilian rural areas (Bovine Vaccinia outbreaks - BV), affecting dairy cattle and milkers. Little is known about VACV's natural hosts and its epidemiological and ecological characteristics. Although VACV was isolated and/or serologically detected in Brazilian wild animals, the link between wildlife and farms has not yet been elucidated. Methodology/Principal Findings: In this study, we describe for the first time, to our knowledge, the isolation of a VACV (Mariana virus - MARV) from a mouse during a BV outbreak. Genetic data, in association with biological assays, showed that this isolate was the same etiological agent causing exanthematic lesions observed in the cattle and human inhabitants of a particular BV-affected area. Phylogenetic analysis grouped MARV with other VACV isolated during BV outbreaks. Conclusion/Significance: These data provide new biological and epidemiological information on VACV and lead to an interesting question: could peridomestic rodents be the link between wildlife and BV outbreaks?

Original languageEnglish (US)
Article numbere7428
JournalPloS one
Volume4
Issue number10
DOIs
StatePublished - Oct 19 2009
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Abrahão, J. S., Guedes, M. I. M., Trindade, G. S., Fonseca, F. G., Kroon Campos, R., Mota, B. F., Lobato, Z. I. P., Silva-Fernandes, A. T., Rodrigues, G. O. L., Lima, L. S., Ferreira, P. C. P., Bonjardim, C. A., & Kroon, E. G. (2009). One more piece in the VACV ecological puzzle: Could peridomestic rodents be the link between wildlife and bovine vaccinia outbreaks in Brazil? PloS one, 4(10), [e7428]. https://doi.org/10.1371/journal.pone.0007428