O’nyong-nyong fever: a neglected mosquito-borne viral disease

Giovanni Rezza, Rubing Chen, Scott C. Weaver

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations


O’nyong nyong virus (ONNV), a mosquito-borne Alphavirus, is primarily transmitted through the bite of Anopheles funestus and Anopheles gambiae mosquitoes, which are also malaria parasite vectors in Africa. The virus, first isolated in Uganda in 1959, is endemic in sub-Saharan Africa and has caused several major outbreaks both in West and East Africa. ONNV fever, characterized by severe arthralgia, is similar to chikungunya fever, with the exception of cervical lymphadenitis, which is peculiar to the former. Prevention measures do not differ from those adopted against malaria parasite transmission. Effective vaccines and drugs are not available, but animal models suggest that vaccine candidates against CHIKV may also confer protection against ONNV.

Original languageEnglish (US)
Pages (from-to)271-275
Number of pages5
JournalPathogens and Global Health
Issue number6
StatePublished - Aug 18 2017


  • O’nyong-nyong
  • alphavirus
  • chikungunya
  • epidemiology

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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