Opioid metabolism: impact of concomitant medications and genetic variations on the interpretation of drug tests

Hila Shaim, Paul E. Young, Anthony O. Okorodudu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Management of chronic pain with opioids is a common practice. Because of the addictive potential of these medications, strict monitoring to ensure compliance is enforced, including routine urine drug tests. Prior to prescribing opioids, medications are metabolized via cytochrome P450 enzymes should be taken into account by care providers. Such medications may need to be discontinued or their doses adjusted for maximal efficacy of pain management regimen. Genetic variation also plays a significant role in metabolism of these medications. Understanding these processes is crucial for physicians who prescribe opioids and clinical toxicologists who interpret the drug test results of patients.

Original languageEnglish (US)
Title of host publicationToxicology Cases for the Clinical and Forensic Laboratory
PublisherElsevier
Pages351-353
Number of pages3
ISBN (Electronic)9780128158463
ISBN (Print)9780128163733
DOIs
StatePublished - Jan 1 2020

Keywords

  • Chronic pain
  • addiction
  • cytochrome P450 enzymes
  • genetic variation
  • opioids
  • toxicology
  • urine drug tests

ASJC Scopus subject areas

  • General Medicine

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