Opioid receptoractivity in CSF from an atypical lower back pain patient

Dominic M. Desiderio, Danxia Liu, George Wood

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

One patient's lumbar CSF sample out of 54 studied for lower back pain had an atypical metabolic profile of opioid receptoractivity. To test our hypothesis that neuropeptides play a role in human lower back pain, endogenous opioid receptoractivity was compared between a control and that atypical sample. Two lumbar puncture samples were obtained from those two patients, one before and one after clinical evaluation. Total opioid receptoractivity was measured in each sample before HPLC separation, and opioid receptoractivity was measured in each fraction after HPLC separation. The latter data represent a metabolic profile of opioid receptoractivity in the human lumbar CSF. Those data demonstrate that the atypical patient had opioid receptoractivity measurements (total and profile) differing in a qualitative and quantitative sense from the other 53 patients studied. CSF opioid receptoractivity reflects the metabolism of opioid neuropeptidergic systems in the physiology in those patients, and opioid peptides may play a role in lower back pain.

Original languageEnglish (US)
Pages (from-to)577-583
Number of pages7
JournalLife Sciences
Volume43
Issue number7
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Low Back Pain
Opioid Analgesics
Metabolome
High Pressure Liquid Chromatography
Spinal Puncture
Opioid Peptides
Physiology
Neuropeptides
Metabolism

ASJC Scopus subject areas

  • Pharmacology

Cite this

Opioid receptoractivity in CSF from an atypical lower back pain patient. / Desiderio, Dominic M.; Liu, Danxia; Wood, George.

In: Life Sciences, Vol. 43, No. 7, 1988, p. 577-583.

Research output: Contribution to journalArticle

Desiderio, Dominic M. ; Liu, Danxia ; Wood, George. / Opioid receptoractivity in CSF from an atypical lower back pain patient. In: Life Sciences. 1988 ; Vol. 43, No. 7. pp. 577-583.
@article{1ec984fd980944488b92e37ffc8156b8,
title = "Opioid receptoractivity in CSF from an atypical lower back pain patient",
abstract = "One patient's lumbar CSF sample out of 54 studied for lower back pain had an atypical metabolic profile of opioid receptoractivity. To test our hypothesis that neuropeptides play a role in human lower back pain, endogenous opioid receptoractivity was compared between a control and that atypical sample. Two lumbar puncture samples were obtained from those two patients, one before and one after clinical evaluation. Total opioid receptoractivity was measured in each sample before HPLC separation, and opioid receptoractivity was measured in each fraction after HPLC separation. The latter data represent a metabolic profile of opioid receptoractivity in the human lumbar CSF. Those data demonstrate that the atypical patient had opioid receptoractivity measurements (total and profile) differing in a qualitative and quantitative sense from the other 53 patients studied. CSF opioid receptoractivity reflects the metabolism of opioid neuropeptidergic systems in the physiology in those patients, and opioid peptides may play a role in lower back pain.",
author = "Desiderio, {Dominic M.} and Danxia Liu and George Wood",
year = "1988",
doi = "10.1016/0024-3205(88)90061-6",
language = "English (US)",
volume = "43",
pages = "577--583",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Opioid receptoractivity in CSF from an atypical lower back pain patient

AU - Desiderio, Dominic M.

AU - Liu, Danxia

AU - Wood, George

PY - 1988

Y1 - 1988

N2 - One patient's lumbar CSF sample out of 54 studied for lower back pain had an atypical metabolic profile of opioid receptoractivity. To test our hypothesis that neuropeptides play a role in human lower back pain, endogenous opioid receptoractivity was compared between a control and that atypical sample. Two lumbar puncture samples were obtained from those two patients, one before and one after clinical evaluation. Total opioid receptoractivity was measured in each sample before HPLC separation, and opioid receptoractivity was measured in each fraction after HPLC separation. The latter data represent a metabolic profile of opioid receptoractivity in the human lumbar CSF. Those data demonstrate that the atypical patient had opioid receptoractivity measurements (total and profile) differing in a qualitative and quantitative sense from the other 53 patients studied. CSF opioid receptoractivity reflects the metabolism of opioid neuropeptidergic systems in the physiology in those patients, and opioid peptides may play a role in lower back pain.

AB - One patient's lumbar CSF sample out of 54 studied for lower back pain had an atypical metabolic profile of opioid receptoractivity. To test our hypothesis that neuropeptides play a role in human lower back pain, endogenous opioid receptoractivity was compared between a control and that atypical sample. Two lumbar puncture samples were obtained from those two patients, one before and one after clinical evaluation. Total opioid receptoractivity was measured in each sample before HPLC separation, and opioid receptoractivity was measured in each fraction after HPLC separation. The latter data represent a metabolic profile of opioid receptoractivity in the human lumbar CSF. Those data demonstrate that the atypical patient had opioid receptoractivity measurements (total and profile) differing in a qualitative and quantitative sense from the other 53 patients studied. CSF opioid receptoractivity reflects the metabolism of opioid neuropeptidergic systems in the physiology in those patients, and opioid peptides may play a role in lower back pain.

UR - http://www.scopus.com/inward/record.url?scp=0023802895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023802895&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(88)90061-6

DO - 10.1016/0024-3205(88)90061-6

M3 - Article

C2 - 2840541

AN - SCOPUS:0023802895

VL - 43

SP - 577

EP - 583

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 7

ER -