Opioid receptors on peripheral sensory axons

Richard E. Coggeshall, Shengtai Zhou, Susan M. Carlton

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

Opioid receptors have been demonstrated by light microscopic techniques in fine cutaneous nerves in naive animals. The present study extends these findings by showing that 29 and 38% of unmyelinated cutaneous sensory axons can be immunostained for μ- or δ-opioid receptors respectively. Local cutaneous injection of DAMGO, a μ-opioid ligand, ameliorates the nociceptive behaviors caused by local cutaneous injection of glutamate, a purely nociceptive chemical stimulus showing that the μ-receptors are functional. By contrast the δ-opioid ligand [2-D-penicillamine, 5-D- penicillamine]enkephalin (DPDPE) had no effect on these behaviors. These findings indicate a wider function for opioid receptors in naive animals than previously envisioned.

Original languageEnglish (US)
Pages (from-to)126-132
Number of pages7
JournalBrain Research
Volume764
Issue number1-2
DOIs
StatePublished - Aug 1 1997

Fingerprint

Opioid Receptors
Axons
Skin
Penicillamine
Opioid Analgesics
Ala(2)-MePhe(4)-Gly(5)-enkephalin
Ligands
Injections
Glutamic Acid
Light

Keywords

  • Endogenous analgesia
  • Glutamate
  • Opioid
  • Ultrastructure
  • Unmyelinated axon

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Coggeshall, R. E., Zhou, S., & Carlton, S. M. (1997). Opioid receptors on peripheral sensory axons. Brain Research, 764(1-2), 126-132. https://doi.org/10.1016/S0006-8993(97)00446-0

Opioid receptors on peripheral sensory axons. / Coggeshall, Richard E.; Zhou, Shengtai; Carlton, Susan M.

In: Brain Research, Vol. 764, No. 1-2, 01.08.1997, p. 126-132.

Research output: Contribution to journalArticle

Coggeshall, RE, Zhou, S & Carlton, SM 1997, 'Opioid receptors on peripheral sensory axons', Brain Research, vol. 764, no. 1-2, pp. 126-132. https://doi.org/10.1016/S0006-8993(97)00446-0
Coggeshall, Richard E. ; Zhou, Shengtai ; Carlton, Susan M. / Opioid receptors on peripheral sensory axons. In: Brain Research. 1997 ; Vol. 764, No. 1-2. pp. 126-132.
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