Opioids regulation of human chorionic gonadotropin release from trophoblast tissue is mediated by gonadotropin releasing hormone

B. Cemerikic, R. Zamah, Mahmoud Ahmed

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In the hypothalamic-pituitary axis opioid regulation of luteinizing hormone secretion occurs via gonadotropin hormone-releasing hormone (GnRH). Trophoblast gonadotropic hormone human chorionic gonadotropin (hCG) and locally produced GnRH in human placenta are similar in structure and biological functions to luteinizing hormone and GnRH from hypothalamic- pituitary axis. In addition, placental kappa receptors mediate opioid regulation of hCG release from trophoblast tissue in vitro and placental GnRH plays a role in regulation of hCG secretion as well. The purpose of this investigation was to determine whether opioids regulation of hCG release from trophoblast tissue is mediated by GnRH. Opioid agonists at their concentrations causing maximal release of hCG from the tissue also stimulated GnRH secretion. Antagonists inhibited the release of hCG and GnRH and totally reversed the effect of agonists, i.e., their effect is kappa receptor mediated. GnRH antagonist inhibited both opioids and GnRH stimulation of hCG release from trophoblast tissue. Neither GnRH nor its antagonist bind to placental kappa receptors. These data suggest that in vitro opioids regulation of hCG release from term trophoblast tissue is mediated by GnRH.

Original languageEnglish (US)
Pages (from-to)971-977
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume268
Issue number2
StatePublished - 1994
Externally publishedYes

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Trophoblasts
Chorionic Gonadotropin
Gonadotropin-Releasing Hormone
Opioid Analgesics
Hormones
kappa Opioid Receptor
Gonadotropins
Placental Hormones
Hypothalamic Hormones
Hormone Antagonists
Pituitary Hormones
Luteinizing Hormone
Placenta

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "Opioids regulation of human chorionic gonadotropin release from trophoblast tissue is mediated by gonadotropin releasing hormone",
abstract = "In the hypothalamic-pituitary axis opioid regulation of luteinizing hormone secretion occurs via gonadotropin hormone-releasing hormone (GnRH). Trophoblast gonadotropic hormone human chorionic gonadotropin (hCG) and locally produced GnRH in human placenta are similar in structure and biological functions to luteinizing hormone and GnRH from hypothalamic- pituitary axis. In addition, placental kappa receptors mediate opioid regulation of hCG release from trophoblast tissue in vitro and placental GnRH plays a role in regulation of hCG secretion as well. The purpose of this investigation was to determine whether opioids regulation of hCG release from trophoblast tissue is mediated by GnRH. Opioid agonists at their concentrations causing maximal release of hCG from the tissue also stimulated GnRH secretion. Antagonists inhibited the release of hCG and GnRH and totally reversed the effect of agonists, i.e., their effect is kappa receptor mediated. GnRH antagonist inhibited both opioids and GnRH stimulation of hCG release from trophoblast tissue. Neither GnRH nor its antagonist bind to placental kappa receptors. These data suggest that in vitro opioids regulation of hCG release from term trophoblast tissue is mediated by GnRH.",
author = "B. Cemerikic and R. Zamah and Mahmoud Ahmed",
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AU - Cemerikic, B.

AU - Zamah, R.

AU - Ahmed, Mahmoud

PY - 1994

Y1 - 1994

N2 - In the hypothalamic-pituitary axis opioid regulation of luteinizing hormone secretion occurs via gonadotropin hormone-releasing hormone (GnRH). Trophoblast gonadotropic hormone human chorionic gonadotropin (hCG) and locally produced GnRH in human placenta are similar in structure and biological functions to luteinizing hormone and GnRH from hypothalamic- pituitary axis. In addition, placental kappa receptors mediate opioid regulation of hCG release from trophoblast tissue in vitro and placental GnRH plays a role in regulation of hCG secretion as well. The purpose of this investigation was to determine whether opioids regulation of hCG release from trophoblast tissue is mediated by GnRH. Opioid agonists at their concentrations causing maximal release of hCG from the tissue also stimulated GnRH secretion. Antagonists inhibited the release of hCG and GnRH and totally reversed the effect of agonists, i.e., their effect is kappa receptor mediated. GnRH antagonist inhibited both opioids and GnRH stimulation of hCG release from trophoblast tissue. Neither GnRH nor its antagonist bind to placental kappa receptors. These data suggest that in vitro opioids regulation of hCG release from term trophoblast tissue is mediated by GnRH.

AB - In the hypothalamic-pituitary axis opioid regulation of luteinizing hormone secretion occurs via gonadotropin hormone-releasing hormone (GnRH). Trophoblast gonadotropic hormone human chorionic gonadotropin (hCG) and locally produced GnRH in human placenta are similar in structure and biological functions to luteinizing hormone and GnRH from hypothalamic- pituitary axis. In addition, placental kappa receptors mediate opioid regulation of hCG release from trophoblast tissue in vitro and placental GnRH plays a role in regulation of hCG secretion as well. The purpose of this investigation was to determine whether opioids regulation of hCG release from trophoblast tissue is mediated by GnRH. Opioid agonists at their concentrations causing maximal release of hCG from the tissue also stimulated GnRH secretion. Antagonists inhibited the release of hCG and GnRH and totally reversed the effect of agonists, i.e., their effect is kappa receptor mediated. GnRH antagonist inhibited both opioids and GnRH stimulation of hCG release from trophoblast tissue. Neither GnRH nor its antagonist bind to placental kappa receptors. These data suggest that in vitro opioids regulation of hCG release from term trophoblast tissue is mediated by GnRH.

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