Opposite synaptic actions mediated by different branches of an identifiable interneuron in aplysia

E. R. Kandel, W. T. Frazier, R. E. Coggeshall

Research output: Contribution to journalArticle

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Abstract

Among the identifiable cells in the abdominal ganglion of Aplysia californica are five that generate bursting rhythms endogenous to the cells. In the four bursting cells of the left upper quadrant the rhythm is modulated by a unitary inhibitory postsynaptic potential; in the bursting cell of the right lower quadrant the rhythm is modulated by a unitary excitatory postsynaptic potential. Both the excitatory and inhibitory postsynaptic potentials are mediated by separate branches of a single interneuron. The pharmacological properties of the double action interneuron as well as those of the follower cells suggest that a single transmitter (acetylcholine) is involved in both the excitatory and the inhibitory action of the interneuron.

Original languageEnglish (US)
Pages (from-to)349-350
Number of pages2
JournalScience
Volume155
Issue number3760
StatePublished - 1967
Externally publishedYes

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Aplysia
Interneurons
Inhibitory Postsynaptic Potentials
Excitatory Postsynaptic Potentials
Ganglia
Acetylcholine
Pharmacology

ASJC Scopus subject areas

  • General

Cite this

Kandel, E. R., Frazier, W. T., & Coggeshall, R. E. (1967). Opposite synaptic actions mediated by different branches of an identifiable interneuron in aplysia. Science, 155(3760), 349-350.

Opposite synaptic actions mediated by different branches of an identifiable interneuron in aplysia. / Kandel, E. R.; Frazier, W. T.; Coggeshall, R. E.

In: Science, Vol. 155, No. 3760, 1967, p. 349-350.

Research output: Contribution to journalArticle

Kandel, ER, Frazier, WT & Coggeshall, RE 1967, 'Opposite synaptic actions mediated by different branches of an identifiable interneuron in aplysia', Science, vol. 155, no. 3760, pp. 349-350.
Kandel, E. R. ; Frazier, W. T. ; Coggeshall, R. E. / Opposite synaptic actions mediated by different branches of an identifiable interneuron in aplysia. In: Science. 1967 ; Vol. 155, No. 3760. pp. 349-350.
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