Optical coherence tomography technique for noninvasive blood glucose monitoring: Phantom, animal, and human studies

Kirill V. Larin, Taras V. Ashitkov, Irina V. Larina, Irina Y. Petrova, Mohsen Eledrisi, Massoud Motamedi, Rinat O. Esenaliev

Research output: Contribution to journalConference article

7 Scopus citations

Abstract

Continuous noninvasive monitoring of blood glucose concentration can improve management of Diabetes Mellitus, reduce mortality, and considerably improve quality of life of diabetic patients. Recently, we proposed to use the OCT technique for noninvasive glucose monitoring. In this paper, we tested noninvasive blood glucose monitoring with the OCT technique in phantoms, animals, and human subjects. An OCT system with the wavelength of 1300 nm was used in our experiments. Phantom studies performed on aqueous suspensions of polystyrene microspheres and milk showed 3.2% decrease of exponential slope of OCT signals when glucose concentration increased from 0 to 100 mM. Theoretical calculations based on the Mie theory of scattering support the results obtained in phantoms. Bolus glucose injections and glucose clamping experiments were performed in animals (New Zealand rabbits and Yucatan micropigs). Good correlation between changes in the OCT signal slope and actual blood glucose concentration were observed in these experiments. First studies were performed in healthy human subjects (using oral glucose tolerance tests). Dependence of the slope of the OCT signals on the actual blood glucose concentration was similar to that obtained in animal studies. Our studies suggest that the OCT technique can potentially be used for noninvasive blood glucose monitoring.

Original languageEnglish (US)
Pages (from-to)157-164
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4619
DOIs
StatePublished - Jan 1 2002
EventCoherence Domain Optical Methods in Biomedical Science and Clinical Applications VI - San Jose, CA, United States
Duration: Jan 21 2002Jan 23 2002

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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