Optical coherence tomography technique for noninvasive blood glucose monitoring

Phantom, animal, and human studies

Kirill V. Larin, Taras V. Ashitkov, Irina V. Larina, Irina Y. Petrova, Mohsen Eledrisi, Massoud Motamedi, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Continuous noninvasive monitoring of blood glucose concentration can improve management of Diabetes Mellitus, reduce mortality, and considerably improve quality of life of diabetic patients. Recently, we proposed to use the OCT technique for noninvasive glucose monitoring. In this paper, we tested noninvasive blood glucose monitoring with the OCT technique in phantoms, animals, and human subjects. An OCT system with the wavelength of 1300 nm was used in our experiments. Phantom studies performed on aqueous suspensions of polystyrene microspheres and milk showed 3.2% decrease of exponential slope of OCT signals when glucose concentration increased from 0 to 100 mM. Theoretical calculations based on the Mie theory of scattering support the results obtained in phantoms. Bolus glucose injections and glucose clamping experiments were performed in animals (New Zealand rabbits and Yucatan micropigs). Good correlation between changes in the OCT signal slope and actual blood glucose concentration were observed in these experiments. First studies were performed in healthy human subjects (using oral glucose tolerance tests). Dependence of the slope of the OCT signals on the actual blood glucose concentration was similar to that obtained in animal studies. Our studies suggest that the OCT technique can potentially be used for noninvasive blood glucose monitoring.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsV.V. Tuchin, J.A. Izatt, J.G. Fujimoto
Pages157-164
Number of pages8
Volume4619
DOIs
StatePublished - 2002
EventCoherence Domain Optical Methods in Biomedical Science and Clinical Applications VI - San Jose, CA, United States
Duration: Jan 21 2002Jan 23 2002

Other

OtherCoherence Domain Optical Methods in Biomedical Science and Clinical Applications VI
CountryUnited States
CitySan Jose, CA
Period1/21/021/23/02

Fingerprint

Optical tomography
glucose
blood
Glucose
animals
Animals
Blood
tomography
Monitoring
slopes
diabetes mellitus
milk
mortality
Experiments
rabbits
New Zealand
Mie scattering
Medical problems
Microspheres
Polystyrenes

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Larin, K. V., Ashitkov, T. V., Larina, I. V., Petrova, I. Y., Eledrisi, M., Motamedi, M., & Esenaliev, R. (2002). Optical coherence tomography technique for noninvasive blood glucose monitoring: Phantom, animal, and human studies. In V. V. Tuchin, J. A. Izatt, & J. G. Fujimoto (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4619, pp. 157-164) https://doi.org/10.1117/12.470478

Optical coherence tomography technique for noninvasive blood glucose monitoring : Phantom, animal, and human studies. / Larin, Kirill V.; Ashitkov, Taras V.; Larina, Irina V.; Petrova, Irina Y.; Eledrisi, Mohsen; Motamedi, Massoud; Esenaliev, Rinat.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / V.V. Tuchin; J.A. Izatt; J.G. Fujimoto. Vol. 4619 2002. p. 157-164.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Larin, KV, Ashitkov, TV, Larina, IV, Petrova, IY, Eledrisi, M, Motamedi, M & Esenaliev, R 2002, Optical coherence tomography technique for noninvasive blood glucose monitoring: Phantom, animal, and human studies. in VV Tuchin, JA Izatt & JG Fujimoto (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4619, pp. 157-164, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI, San Jose, CA, United States, 1/21/02. https://doi.org/10.1117/12.470478
Larin KV, Ashitkov TV, Larina IV, Petrova IY, Eledrisi M, Motamedi M et al. Optical coherence tomography technique for noninvasive blood glucose monitoring: Phantom, animal, and human studies. In Tuchin VV, Izatt JA, Fujimoto JG, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4619. 2002. p. 157-164 https://doi.org/10.1117/12.470478
Larin, Kirill V. ; Ashitkov, Taras V. ; Larina, Irina V. ; Petrova, Irina Y. ; Eledrisi, Mohsen ; Motamedi, Massoud ; Esenaliev, Rinat. / Optical coherence tomography technique for noninvasive blood glucose monitoring : Phantom, animal, and human studies. Proceedings of SPIE - The International Society for Optical Engineering. editor / V.V. Tuchin ; J.A. Izatt ; J.G. Fujimoto. Vol. 4619 2002. pp. 157-164
@inproceedings{660442bceb2b4566aa4fa429b9e66ab9,
title = "Optical coherence tomography technique for noninvasive blood glucose monitoring: Phantom, animal, and human studies",
abstract = "Continuous noninvasive monitoring of blood glucose concentration can improve management of Diabetes Mellitus, reduce mortality, and considerably improve quality of life of diabetic patients. Recently, we proposed to use the OCT technique for noninvasive glucose monitoring. In this paper, we tested noninvasive blood glucose monitoring with the OCT technique in phantoms, animals, and human subjects. An OCT system with the wavelength of 1300 nm was used in our experiments. Phantom studies performed on aqueous suspensions of polystyrene microspheres and milk showed 3.2{\%} decrease of exponential slope of OCT signals when glucose concentration increased from 0 to 100 mM. Theoretical calculations based on the Mie theory of scattering support the results obtained in phantoms. Bolus glucose injections and glucose clamping experiments were performed in animals (New Zealand rabbits and Yucatan micropigs). Good correlation between changes in the OCT signal slope and actual blood glucose concentration were observed in these experiments. First studies were performed in healthy human subjects (using oral glucose tolerance tests). Dependence of the slope of the OCT signals on the actual blood glucose concentration was similar to that obtained in animal studies. Our studies suggest that the OCT technique can potentially be used for noninvasive blood glucose monitoring.",
author = "Larin, {Kirill V.} and Ashitkov, {Taras V.} and Larina, {Irina V.} and Petrova, {Irina Y.} and Mohsen Eledrisi and Massoud Motamedi and Rinat Esenaliev",
year = "2002",
doi = "10.1117/12.470478",
language = "English (US)",
volume = "4619",
pages = "157--164",
editor = "V.V. Tuchin and J.A. Izatt and J.G. Fujimoto",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

TY - GEN

T1 - Optical coherence tomography technique for noninvasive blood glucose monitoring

T2 - Phantom, animal, and human studies

AU - Larin, Kirill V.

AU - Ashitkov, Taras V.

AU - Larina, Irina V.

AU - Petrova, Irina Y.

AU - Eledrisi, Mohsen

AU - Motamedi, Massoud

AU - Esenaliev, Rinat

PY - 2002

Y1 - 2002

N2 - Continuous noninvasive monitoring of blood glucose concentration can improve management of Diabetes Mellitus, reduce mortality, and considerably improve quality of life of diabetic patients. Recently, we proposed to use the OCT technique for noninvasive glucose monitoring. In this paper, we tested noninvasive blood glucose monitoring with the OCT technique in phantoms, animals, and human subjects. An OCT system with the wavelength of 1300 nm was used in our experiments. Phantom studies performed on aqueous suspensions of polystyrene microspheres and milk showed 3.2% decrease of exponential slope of OCT signals when glucose concentration increased from 0 to 100 mM. Theoretical calculations based on the Mie theory of scattering support the results obtained in phantoms. Bolus glucose injections and glucose clamping experiments were performed in animals (New Zealand rabbits and Yucatan micropigs). Good correlation between changes in the OCT signal slope and actual blood glucose concentration were observed in these experiments. First studies were performed in healthy human subjects (using oral glucose tolerance tests). Dependence of the slope of the OCT signals on the actual blood glucose concentration was similar to that obtained in animal studies. Our studies suggest that the OCT technique can potentially be used for noninvasive blood glucose monitoring.

AB - Continuous noninvasive monitoring of blood glucose concentration can improve management of Diabetes Mellitus, reduce mortality, and considerably improve quality of life of diabetic patients. Recently, we proposed to use the OCT technique for noninvasive glucose monitoring. In this paper, we tested noninvasive blood glucose monitoring with the OCT technique in phantoms, animals, and human subjects. An OCT system with the wavelength of 1300 nm was used in our experiments. Phantom studies performed on aqueous suspensions of polystyrene microspheres and milk showed 3.2% decrease of exponential slope of OCT signals when glucose concentration increased from 0 to 100 mM. Theoretical calculations based on the Mie theory of scattering support the results obtained in phantoms. Bolus glucose injections and glucose clamping experiments were performed in animals (New Zealand rabbits and Yucatan micropigs). Good correlation between changes in the OCT signal slope and actual blood glucose concentration were observed in these experiments. First studies were performed in healthy human subjects (using oral glucose tolerance tests). Dependence of the slope of the OCT signals on the actual blood glucose concentration was similar to that obtained in animal studies. Our studies suggest that the OCT technique can potentially be used for noninvasive blood glucose monitoring.

UR - http://www.scopus.com/inward/record.url?scp=0036402870&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036402870&partnerID=8YFLogxK

U2 - 10.1117/12.470478

DO - 10.1117/12.470478

M3 - Conference contribution

VL - 4619

SP - 157

EP - 164

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Tuchin, V.V.

A2 - Izatt, J.A.

A2 - Fujimoto, J.G.

ER -