Optimal examination of the normally formed perinatal heart

William H. Donnelly, Hal Hawkins

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Because infant rarely suffer coronary artery thrombosis, it is mistakenly assumed that they seldom have significant ischemic myocardial injury. However, ischemic myocardial necrosis (INM) is common in the papillary muscles and subendocardium of stressed newborns and other infants. Standard dissection methods encourage only routine examination and limited sampling of the small perinatal heart, and most myocardial injury is never discovered. After evaluating published methods, a simple technique was developed to open and prepare the normally formed infant heart for optimal macroscopic and microscopic evaluation. Symmetrical anterior incisions of the atria and ventricles allow the atria, ventricles, and outflow tracts to be viewed almost simultaneously. A single change allows the heart to be "unrolled" into a plane for roentgenographic study of injected coronary arteries. The method for sampling the myocardium and the conduction system allows identification of more than 90 per cent of the IMN sites without adding significant costs. The recognition of significant IMN plays a valuable role in evaluating and explaining certain infant deaths.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalHuman Pathology
Volume18
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Coronary Vessels
Coronary Thrombosis
Papillary Muscles
Wounds and Injuries
Dissection
Myocardium
Necrosis
Newborn Infant
Costs and Cost Analysis
Infant Death

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Optimal examination of the normally formed perinatal heart. / Donnelly, William H.; Hawkins, Hal.

In: Human Pathology, Vol. 18, No. 1, 1987, p. 55-60.

Research output: Contribution to journalArticle

Donnelly, William H. ; Hawkins, Hal. / Optimal examination of the normally formed perinatal heart. In: Human Pathology. 1987 ; Vol. 18, No. 1. pp. 55-60.
@article{15c58f5f4b6c4ae285dfa58bdf037bbb,
title = "Optimal examination of the normally formed perinatal heart",
abstract = "Because infant rarely suffer coronary artery thrombosis, it is mistakenly assumed that they seldom have significant ischemic myocardial injury. However, ischemic myocardial necrosis (INM) is common in the papillary muscles and subendocardium of stressed newborns and other infants. Standard dissection methods encourage only routine examination and limited sampling of the small perinatal heart, and most myocardial injury is never discovered. After evaluating published methods, a simple technique was developed to open and prepare the normally formed infant heart for optimal macroscopic and microscopic evaluation. Symmetrical anterior incisions of the atria and ventricles allow the atria, ventricles, and outflow tracts to be viewed almost simultaneously. A single change allows the heart to be {"}unrolled{"} into a plane for roentgenographic study of injected coronary arteries. The method for sampling the myocardium and the conduction system allows identification of more than 90 per cent of the IMN sites without adding significant costs. The recognition of significant IMN plays a valuable role in evaluating and explaining certain infant deaths.",
author = "Donnelly, {William H.} and Hal Hawkins",
year = "1987",
doi = "10.1016/S0046-8177(87)80194-6",
language = "English (US)",
volume = "18",
pages = "55--60",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Optimal examination of the normally formed perinatal heart

AU - Donnelly, William H.

AU - Hawkins, Hal

PY - 1987

Y1 - 1987

N2 - Because infant rarely suffer coronary artery thrombosis, it is mistakenly assumed that they seldom have significant ischemic myocardial injury. However, ischemic myocardial necrosis (INM) is common in the papillary muscles and subendocardium of stressed newborns and other infants. Standard dissection methods encourage only routine examination and limited sampling of the small perinatal heart, and most myocardial injury is never discovered. After evaluating published methods, a simple technique was developed to open and prepare the normally formed infant heart for optimal macroscopic and microscopic evaluation. Symmetrical anterior incisions of the atria and ventricles allow the atria, ventricles, and outflow tracts to be viewed almost simultaneously. A single change allows the heart to be "unrolled" into a plane for roentgenographic study of injected coronary arteries. The method for sampling the myocardium and the conduction system allows identification of more than 90 per cent of the IMN sites without adding significant costs. The recognition of significant IMN plays a valuable role in evaluating and explaining certain infant deaths.

AB - Because infant rarely suffer coronary artery thrombosis, it is mistakenly assumed that they seldom have significant ischemic myocardial injury. However, ischemic myocardial necrosis (INM) is common in the papillary muscles and subendocardium of stressed newborns and other infants. Standard dissection methods encourage only routine examination and limited sampling of the small perinatal heart, and most myocardial injury is never discovered. After evaluating published methods, a simple technique was developed to open and prepare the normally formed infant heart for optimal macroscopic and microscopic evaluation. Symmetrical anterior incisions of the atria and ventricles allow the atria, ventricles, and outflow tracts to be viewed almost simultaneously. A single change allows the heart to be "unrolled" into a plane for roentgenographic study of injected coronary arteries. The method for sampling the myocardium and the conduction system allows identification of more than 90 per cent of the IMN sites without adding significant costs. The recognition of significant IMN plays a valuable role in evaluating and explaining certain infant deaths.

UR - http://www.scopus.com/inward/record.url?scp=0023158574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023158574&partnerID=8YFLogxK

U2 - 10.1016/S0046-8177(87)80194-6

DO - 10.1016/S0046-8177(87)80194-6

M3 - Article

C2 - 3817800

AN - SCOPUS:0023158574

VL - 18

SP - 55

EP - 60

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 1

ER -