Optimization of low coherence interferometry for quantitative analysis of tissue optical properties

Alexander I. Kholodnykh, Irina Y. Petrova, Kirill V. Larin, Massoud Motamedi, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Citations (Scopus)

Abstract

Noninvasive monitoring of analytes can be performed with optical coherence tomography (OCT) technique. This technique may allow measurement of optical properties of tissue (attenuation, scattering, optical thickness, etc.) that may be dependent on analyte concentration. Accurate monitoring of analyte concentration requires measurement of the optical properties with high accuracy. The accuracy of measurements depends on OCT technical characteristics and the level of speckle noise. In this paper, we report the results of the calibration of OCT system sensitivity for absolute and relative measurements of the backscattering and total attenuation coefficients in scattering standard, tissue phantoms (suspensions of polystyrene microspheres in water solutions of glucose), and human skin. We measured the OCT sensitivity as a function of depth and used this dependence for correction of signals. The amplitude and spatial period of backscattered signal modulation resulted from speckle noise were measured for the scattering standard and human skin. The dependence of speckle and electronic noise on the range of spatial and temporal averaging of OCT signals was determined. Our studies show that the accuracy of measurement of changes in optical properties of tissue with OCT technique can be significantly improved by reducing of speckle noise and by using the signal correction algorithm.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Pages36-46
Number of pages11
Volume4624
DOIs
StatePublished - 2002
EventOptical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II - San Jose, CA, United States
Duration: Jan 23 2002Jan 24 2002

Other

OtherOptical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II
CountryUnited States
CitySan Jose, CA
Period1/23/021/24/02

Fingerprint

Optical tomography
Interferometry
quantitative analysis
interferometry
Optical properties
tomography
Tissue
Speckle
optical properties
optimization
Chemical analysis
Scattering
Skin
scattering
Monitoring
sensitivity
attenuation coefficients
Backscattering
Microspheres
glucose

Keywords

  • Glucose sensing
  • Laser interferometry
  • Noninvasive monitoring
  • Optical coherence tomography

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Kholodnykh, A. I., Petrova, I. Y., Larin, K. V., Motamedi, M., & Esenaliev, R. (2002). Optimization of low coherence interferometry for quantitative analysis of tissue optical properties. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4624, pp. 36-46) https://doi.org/10.1117/12.468325

Optimization of low coherence interferometry for quantitative analysis of tissue optical properties. / Kholodnykh, Alexander I.; Petrova, Irina Y.; Larin, Kirill V.; Motamedi, Massoud; Esenaliev, Rinat.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4624 2002. p. 36-46.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kholodnykh, AI, Petrova, IY, Larin, KV, Motamedi, M & Esenaliev, R 2002, Optimization of low coherence interferometry for quantitative analysis of tissue optical properties. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 4624, pp. 36-46, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, San Jose, CA, United States, 1/23/02. https://doi.org/10.1117/12.468325
Kholodnykh AI, Petrova IY, Larin KV, Motamedi M, Esenaliev R. Optimization of low coherence interferometry for quantitative analysis of tissue optical properties. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4624. 2002. p. 36-46 https://doi.org/10.1117/12.468325
Kholodnykh, Alexander I. ; Petrova, Irina Y. ; Larin, Kirill V. ; Motamedi, Massoud ; Esenaliev, Rinat. / Optimization of low coherence interferometry for quantitative analysis of tissue optical properties. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4624 2002. pp. 36-46
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