Optimized production and immunogenicity of an insect virus-based chikungunya virus candidate vaccine in cell culture and animal models

Medicine & Life Sciences

• Insect Viruses 100%
• Chikungunya virus 82%
• Eilat virus 45%
• Cell Culture Techniques 45%
• Vaccines 44%
• Animal Models 42%
• Adaptive Immunity 40%
• T-Lymphocytes 36%
• B-Lymphocytes 30%
• Viruses 26%
• Attenuated Vaccines 24%
• Culicidae 21%
• Antigen-Presenting Cells 20%
• Innate Immunity 18%
• Immunoglobulin M 17%
• Antiviral Agents 16%
• Immunity 16%
• Vaccination 15%
• Immunoglobulin G 14%
• Kinetics 14%
• Cytokines 12%
• Antibodies 10%
• Animals 9%
• In Vitro Techniques 8%

Agriculture & Biology

• Chikungunya virus 89%
• insect viruses 84%
• immunogenicity 70%
• animal models 51%
• vaccines 51%
• cell culture 47%
• T-lymphocytes 14%
• adaptive immunity 12%
• B-lymphocytes 10%
• antigen-presenting cells 7%
• viruses 6%
• mice 6%
• hypersensitive response 5%
• dosage 5%
• innate immunity 5%
• cytokines 5%
• vaccination 4%
• immunity 4%
• Culicidae 4%
• antibodies 3%
• kinetics 3%
• cells 3%
• animals 2%

Chemical Compounds

• Dose 45%
• Inducer 34%
• Sensitization 31%
• Antigen 24%
• Strain 20%