Optoacoustic detection and monitoring of blast-induced intracranial hematomas in rats

Andrey Petrov, Karon E. Wynne, Donald Prough, Douglas Dewitt, Yuriy Petrov, Irene Y. Petrov, Margaret A. Parsley, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Patients with acute intracranial hematomas often require surgical drainage within the first four hours after traumatic brain injury (TBI) to avoid death or severe neurologic disability. CT and MRI permit rapid, noninvasive diagnosis of hematomas, but can be used only at a major health-care facility. At present, there is no device for noninvasive detection and characterization of hematomas in pre-hospital settings. We proposed to use an optoacoustic technique for rapid, noninvasive diagnosis and monitoring of hematomas, including intracranial hematomas. Unlike bulky CT and MR equipment, an optoacoustic system can be small and easily transported in an emergency vehicle. In this study we used a specially-designed blast device to inflict TBI in rats. A near-infrared OPO-based optoacoustic system developed for hematoma diagnosis and for blood oxygenation monitoring in the superior sagittal sinus (SSS) in small animals was used in the study. Optoacoustic signals recorded simultaneously from the SSS and hematomas allowed for measurements of their oxygenations. The presence of hematomas was confirmed after the experiment in gross pictures of the exposed brains. After blast the hematoma signal and oxygenation increased, while SSS oxygenation decreased due to the blastinduced TBI. The increase of the oxygenation in fresh hematomas may be explained by the leakage of blood from arteries which have higher blood pressure compared to that of veins. These results indicate that the optoacoustic technique can be used for early diagnosis of hematomas and may provide important information for improving outcomes in patients with TBI or stroke (both hemorrhagic and ischemic).

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8943
ISBN (Print)9780819498564
DOIs
StatePublished - 2014
EventPhotons Plus Ultrasound: Imaging and Sensing 2014 - San Francisco, CA, United States
Duration: Feb 2 2014Feb 5 2014

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2014
CountryUnited States
CitySan Francisco, CA
Period2/2/142/5/14

Fingerprint

Oxygenation
Photoacoustic effect
oxygenation
brain damage
blasts
Hematoma
rats
Rats
Brain
sinuses
Monitoring
Superior Sagittal Sinus
blood
Blood
Photoacoustic Techniques
Emergency vehicles
disabilities
blood pressure
Blood pressure
emergencies

Keywords

  • Animal model
  • Blast
  • Cerebral blood oxygenation
  • Diagnosis
  • Hematoma
  • Noninvasive monitoring
  • Optoacoustics
  • Traumatic brain injury

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Petrov, A., Wynne, K. E., Prough, D., Dewitt, D., Petrov, Y., Petrov, I. Y., ... Esenaliev, R. (2014). Optoacoustic detection and monitoring of blast-induced intracranial hematomas in rats. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8943). [894350] SPIE. https://doi.org/10.1117/12.2045357

Optoacoustic detection and monitoring of blast-induced intracranial hematomas in rats. / Petrov, Andrey; Wynne, Karon E.; Prough, Donald; Dewitt, Douglas; Petrov, Yuriy; Petrov, Irene Y.; Parsley, Margaret A.; Esenaliev, Rinat.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8943 SPIE, 2014. 894350.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Petrov, A, Wynne, KE, Prough, D, Dewitt, D, Petrov, Y, Petrov, IY, Parsley, MA & Esenaliev, R 2014, Optoacoustic detection and monitoring of blast-induced intracranial hematomas in rats. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8943, 894350, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2014, San Francisco, CA, United States, 2/2/14. https://doi.org/10.1117/12.2045357
Petrov A, Wynne KE, Prough D, Dewitt D, Petrov Y, Petrov IY et al. Optoacoustic detection and monitoring of blast-induced intracranial hematomas in rats. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8943. SPIE. 2014. 894350 https://doi.org/10.1117/12.2045357
Petrov, Andrey ; Wynne, Karon E. ; Prough, Donald ; Dewitt, Douglas ; Petrov, Yuriy ; Petrov, Irene Y. ; Parsley, Margaret A. ; Esenaliev, Rinat. / Optoacoustic detection and monitoring of blast-induced intracranial hematomas in rats. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8943 SPIE, 2014.
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