Optoacoustic detection of intra- and extracranial hematomas in rats after blast injury

Andrey Petrov, Karon E. Wynne, Margaret A. Parsley, Irene Y. Petrov, Yuriy Petrov, Katherine A. Ruppert, Donald Prough, Douglas Dewitt, Rinat Esenaliev

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Surgical drainage of intracranial hematomas is often required within the first four hours after traumatic brain injury (TBI) to avoid death or severe disability. Although CT and MRI permit hematoma diagnosis, they can be used only at a major health-care facility. This delays hematoma diagnosis and therapy. We proposed to use an optoacoustic technique for rapid, noninvasive diagnosis of hematomas. In this study we developed a near-infrared OPO-based optoacoustic system for hematoma diagnosis and cerebral venous blood oxygenation monitoring in rats. A specially-designed blast device was used to inflict TBI in anesthetized rats. Optoacoustic signals were recorded from the superior sagittal sinus and hematomas that allowed for measurements of their oxygenations. These results indicate that the optoacoustic technique may be used for early diagnosis of hematomas and may provide important information for improving outcomes in patients with TBI.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalPhotoacoustics
Volume2
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Blast Injuries
blasts
Hematoma
rats
brain damage
Photoacoustic Techniques
oxygenation
disabilities
sinuses
drainage
Superior Sagittal Sinus
death
health
blood
therapy
Health Facilities
Early Diagnosis
Drainage
Delivery of Health Care
Equipment and Supplies

Keywords

  • Animal model
  • Blast
  • Cerebral blood oxygenation
  • Hematoma
  • Noninvasive monitoring
  • Optoacoustics
  • Traumatic brain injury

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Petrov, A., Wynne, K. E., Parsley, M. A., Petrov, I. Y., Petrov, Y., Ruppert, K. A., ... Esenaliev, R. (2014). Optoacoustic detection of intra- and extracranial hematomas in rats after blast injury. Photoacoustics, 2(2), 75-80. https://doi.org/10.1016/j.pacs.2014.04.001

Optoacoustic detection of intra- and extracranial hematomas in rats after blast injury. / Petrov, Andrey; Wynne, Karon E.; Parsley, Margaret A.; Petrov, Irene Y.; Petrov, Yuriy; Ruppert, Katherine A.; Prough, Donald; Dewitt, Douglas; Esenaliev, Rinat.

In: Photoacoustics, Vol. 2, No. 2, 2014, p. 75-80.

Research output: Contribution to journalArticle

Petrov, Andrey ; Wynne, Karon E. ; Parsley, Margaret A. ; Petrov, Irene Y. ; Petrov, Yuriy ; Ruppert, Katherine A. ; Prough, Donald ; Dewitt, Douglas ; Esenaliev, Rinat. / Optoacoustic detection of intra- and extracranial hematomas in rats after blast injury. In: Photoacoustics. 2014 ; Vol. 2, No. 2. pp. 75-80.
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