TY - JOUR
T1 - Optoacoustic diagnostic modality
T2 - From idea to clinical studies with highly compact laser diode-based systems
AU - Esenaliev, Rinat O.
N1 - Funding Information:
The author thanks Drs. Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, Claudia S. Robertson, C. Joan Richardson, other members of the Department of Anesthesiology, Department of Pediatrics and Neonatal Intensive Care Unit at UTMB, and the Department of Neurosurgery and Neurointensive Care Unit of Baylor College of Medicine. Grant support: NIH grants #R01EB00763 and #U54EB007954 from the National Institute of Biomedical Imaging and Bioengineering, #R01NS044345 and #R21NS40531 from the National Institute of Neurological Disorders and Stroke, #R41HD076568 and #R43HD075551 from Eunice Kennedy Shriver National Institute of Child Health and Human Development, and #R41HL10309501 from the National Heart, Lung and Blood Institute, contracts from Noninvasix, Inc., Texas Emerging Technology Fund, and Moody Center for Brain and Spinal Cord Injury Research/ Mission Connect of UTMB. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIBIB or NIH.
Publisher Copyright:
© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Optoacoustic (photoacoustic) diagnostic modality is a technique that combines high optical contrast and ultrasound spatial resolution. We proposed using the optoacoustic technique for a number of applications, including cancer detection, monitoring of thermotherapy (hyperthermia, coagulation, and freezing), monitoring of cerebral blood oxygenation in patients with traumatic brain injury, neonatal patients, fetuses during late-stage labor, central venous oxygenation monitoring, and total hemoglobin concentration monitoring as well as hematoma detection and characterization. We developed and built optical parametric oscillator-based systems and multiwavelength, fiber-coupled highly compact, laser diode-based systems for optoacoustic imaging, monitoring, and sensing. To provide sufficient output pulse energy, a specially designed fiber-optic system was built and incorporated in ultrasensitive, wideband optoacoustic probes. We performed preclinical and clinical tests of the systems and the optoacoustic probes in backward mode for most of the applications and in forward mode for the breast cancer and cerebral applications. The high pulse energy and repetition rate allowed for rapid data acquisition with high signal-to-noise ratio from cerebral blood vessels, such as the superior sagittal sinus, central veins, and peripheral veins and arteries, as well as from intracranial hematomas. The optoacoustic systems were capable of automatic, real-time, continuous measurements of blood oxygenation in these blood vessels.
AB - Optoacoustic (photoacoustic) diagnostic modality is a technique that combines high optical contrast and ultrasound spatial resolution. We proposed using the optoacoustic technique for a number of applications, including cancer detection, monitoring of thermotherapy (hyperthermia, coagulation, and freezing), monitoring of cerebral blood oxygenation in patients with traumatic brain injury, neonatal patients, fetuses during late-stage labor, central venous oxygenation monitoring, and total hemoglobin concentration monitoring as well as hematoma detection and characterization. We developed and built optical parametric oscillator-based systems and multiwavelength, fiber-coupled highly compact, laser diode-based systems for optoacoustic imaging, monitoring, and sensing. To provide sufficient output pulse energy, a specially designed fiber-optic system was built and incorporated in ultrasensitive, wideband optoacoustic probes. We performed preclinical and clinical tests of the systems and the optoacoustic probes in backward mode for most of the applications and in forward mode for the breast cancer and cerebral applications. The high pulse energy and repetition rate allowed for rapid data acquisition with high signal-to-noise ratio from cerebral blood vessels, such as the superior sagittal sinus, central veins, and peripheral veins and arteries, as well as from intracranial hematomas. The optoacoustic systems were capable of automatic, real-time, continuous measurements of blood oxygenation in these blood vessels.
KW - cancer detection
KW - imaging
KW - monitoring
KW - optoacoustic
KW - oxygenation
KW - photoacoustic
KW - thermotherapy
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U2 - 10.1117/1.JBO.22.9.091512
DO - 10.1117/1.JBO.22.9.091512
M3 - Article
C2 - 28444150
AN - SCOPUS:85021677389
SN - 1083-3668
VL - 22
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 9
M1 - 091512
ER -