Optoacoustic imaging of blood vessels

I. Patrikeev, H. P. Brecht, Y. Y. Petrov, I. Y. Petrova, D. S. Prough, R. O. Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optoacoustic imaging, a novel noninvasive modality, combines the advantages of optical methods and the ultrasound technique. The optoacoustic technique is based on tissue irradiation with nanosecond laser pulses and detection of ultrasound waves generated due to thermo-elastic expansion. Using a modified Monte Carlo technique and solution of wave equation for velocity potential, we modeled optoacoustic signals from cylindrical blood vessels with varying oxygenation and varying total hemoglobin concentration. A specially designed computer code was used for reconstruction of images of absorbed energy in the blood vessels and surrounding tissues. Then we performed a set of experiments with our optoacoustic system and phantoms that simulate blood vessels such as veins and arteries at depths of up to 2 cm. The optoacoustic signals from the phantoms were used for reconstruction of 2-D cross-section images and correlated well with geometry and optical properties of the phantoms. The obtained data suggest that the developed optoacoustic imaging approach can be used for accurate mapping of blood oxygenation and hemoglobin concentration in blood vessels.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2007
Subtitle of host publicationUltrasonic Imaging and Signal Processing
DOIs
StatePublished - Oct 15 2007
EventMedical Imaging 2007: Ultrasonic Imaging and Signal Processing - San Diego, CA, United States
Duration: Feb 18 2007Feb 19 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6513
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2007: Ultrasonic Imaging and Signal Processing
CountryUnited States
CitySan Diego, CA
Period2/18/072/19/07

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Keywords

  • Filtered back-projection
  • Monte Carlo simulation
  • Optoacoustic monitoring

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Patrikeev, I., Brecht, H. P., Petrov, Y. Y., Petrova, I. Y., Prough, D. S., & Esenaliev, R. O. (2007). Optoacoustic imaging of blood vessels. In Medical Imaging 2007: Ultrasonic Imaging and Signal Processing [65130R] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6513). https://doi.org/10.1117/12.711176