Optoacoustic imaging of the prostate

Development toward image-guided biopsy

Mohammad A. Yaseen, Sergey A. Ermilov, Hans Peter Brecht, Richard Su, André Conjusteau, Matthew Fronheiser, Brent A. Bell, Massoud Motamedi, Alexander A. Oraevsky

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Optoacoustic (OA) tomography has demonstrated utility in identifying blood-rich malignancies in breast tissue. We describe the development and characterization of a laser OA imaging system for the prostate (LOIS-P). The system consists of a fiber-coupled Q-switched laser operating at 757 nm, a commercial 128-channel ultrasonic probe, a digital signal processor, and software that, uses the filtered radial back-projection algorithm for image reconstruction. The system is used to reconstruct OA images of a blood-rich lesion in-duced in vivo in a canine prostate. OA images obtained in vivo are compared to images acquired using ultrasound, the current gold stan-dard for guiding biopsy of the prostate. Although key structural fea-tures such as the urethra could be identified with both imaging tech-niques, a bloody lesion representing a highly vascularized tumor could only be clearly identified in OA images. The advantages and limitations of both forward and backward illumination modes are also evaluated by collecting OA images of phantoms simulating blood ves-sels within tissue. System resolution is estimated to be 0.2 mm in the radial direction of the acoustic array. The minimum detectable pres-sure signal is 1.83 Pa. Our results encourage further development toward a dual-modality OA/ultrasonic system for prostate imaging and image-guided biopsy.

Original languageEnglish (US)
Article number021310
JournalJournal of Biomedical Optics
Volume15
Issue number2
DOIs
StatePublished - 2010

Fingerprint

Photoacoustic effect
Biopsy
Imaging techniques
blood
Blood
Ultrasonics
lesions
ultrasonics
Acoustic arrays
Tissue
Q switched lasers
Optical fiber coupling
image reconstruction
breast
Digital signal processors
central processing units
Image reconstruction
Gold
Imaging systems
tumors

Keywords

  • Image reconstruction
  • Optoacoustic tomography
  • Prostate cancer
  • Tran-srectal ultrasound imaging
  • Tumor imaging

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Yaseen, M. A., Ermilov, S. A., Brecht, H. P., Su, R., Conjusteau, A., Fronheiser, M., ... Oraevsky, A. A. (2010). Optoacoustic imaging of the prostate: Development toward image-guided biopsy. Journal of Biomedical Optics, 15(2), [021310]. https://doi.org/10.1117/1.3333548

Optoacoustic imaging of the prostate : Development toward image-guided biopsy. / Yaseen, Mohammad A.; Ermilov, Sergey A.; Brecht, Hans Peter; Su, Richard; Conjusteau, André; Fronheiser, Matthew; Bell, Brent A.; Motamedi, Massoud; Oraevsky, Alexander A.

In: Journal of Biomedical Optics, Vol. 15, No. 2, 021310, 2010.

Research output: Contribution to journalArticle

Yaseen, MA, Ermilov, SA, Brecht, HP, Su, R, Conjusteau, A, Fronheiser, M, Bell, BA, Motamedi, M & Oraevsky, AA 2010, 'Optoacoustic imaging of the prostate: Development toward image-guided biopsy', Journal of Biomedical Optics, vol. 15, no. 2, 021310. https://doi.org/10.1117/1.3333548
Yaseen MA, Ermilov SA, Brecht HP, Su R, Conjusteau A, Fronheiser M et al. Optoacoustic imaging of the prostate: Development toward image-guided biopsy. Journal of Biomedical Optics. 2010;15(2). 021310. https://doi.org/10.1117/1.3333548
Yaseen, Mohammad A. ; Ermilov, Sergey A. ; Brecht, Hans Peter ; Su, Richard ; Conjusteau, André ; Fronheiser, Matthew ; Bell, Brent A. ; Motamedi, Massoud ; Oraevsky, Alexander A. / Optoacoustic imaging of the prostate : Development toward image-guided biopsy. In: Journal of Biomedical Optics. 2010 ; Vol. 15, No. 2.
@article{bf744530a6774b98a0cd3dc1ab00c66d,
title = "Optoacoustic imaging of the prostate: Development toward image-guided biopsy",
abstract = "Optoacoustic (OA) tomography has demonstrated utility in identifying blood-rich malignancies in breast tissue. We describe the development and characterization of a laser OA imaging system for the prostate (LOIS-P). The system consists of a fiber-coupled Q-switched laser operating at 757 nm, a commercial 128-channel ultrasonic probe, a digital signal processor, and software that, uses the filtered radial back-projection algorithm for image reconstruction. The system is used to reconstruct OA images of a blood-rich lesion in-duced in vivo in a canine prostate. OA images obtained in vivo are compared to images acquired using ultrasound, the current gold stan-dard for guiding biopsy of the prostate. Although key structural fea-tures such as the urethra could be identified with both imaging tech-niques, a bloody lesion representing a highly vascularized tumor could only be clearly identified in OA images. The advantages and limitations of both forward and backward illumination modes are also evaluated by collecting OA images of phantoms simulating blood ves-sels within tissue. System resolution is estimated to be 0.2 mm in the radial direction of the acoustic array. The minimum detectable pres-sure signal is 1.83 Pa. Our results encourage further development toward a dual-modality OA/ultrasonic system for prostate imaging and image-guided biopsy.",
keywords = "Image reconstruction, Optoacoustic tomography, Prostate cancer, Tran-srectal ultrasound imaging, Tumor imaging",
author = "Yaseen, {Mohammad A.} and Ermilov, {Sergey A.} and Brecht, {Hans Peter} and Richard Su and Andr{\'e} Conjusteau and Matthew Fronheiser and Bell, {Brent A.} and Massoud Motamedi and Oraevsky, {Alexander A.}",
year = "2010",
doi = "10.1117/1.3333548",
language = "English (US)",
volume = "15",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "2",

}

TY - JOUR

T1 - Optoacoustic imaging of the prostate

T2 - Development toward image-guided biopsy

AU - Yaseen, Mohammad A.

AU - Ermilov, Sergey A.

AU - Brecht, Hans Peter

AU - Su, Richard

AU - Conjusteau, André

AU - Fronheiser, Matthew

AU - Bell, Brent A.

AU - Motamedi, Massoud

AU - Oraevsky, Alexander A.

PY - 2010

Y1 - 2010

N2 - Optoacoustic (OA) tomography has demonstrated utility in identifying blood-rich malignancies in breast tissue. We describe the development and characterization of a laser OA imaging system for the prostate (LOIS-P). The system consists of a fiber-coupled Q-switched laser operating at 757 nm, a commercial 128-channel ultrasonic probe, a digital signal processor, and software that, uses the filtered radial back-projection algorithm for image reconstruction. The system is used to reconstruct OA images of a blood-rich lesion in-duced in vivo in a canine prostate. OA images obtained in vivo are compared to images acquired using ultrasound, the current gold stan-dard for guiding biopsy of the prostate. Although key structural fea-tures such as the urethra could be identified with both imaging tech-niques, a bloody lesion representing a highly vascularized tumor could only be clearly identified in OA images. The advantages and limitations of both forward and backward illumination modes are also evaluated by collecting OA images of phantoms simulating blood ves-sels within tissue. System resolution is estimated to be 0.2 mm in the radial direction of the acoustic array. The minimum detectable pres-sure signal is 1.83 Pa. Our results encourage further development toward a dual-modality OA/ultrasonic system for prostate imaging and image-guided biopsy.

AB - Optoacoustic (OA) tomography has demonstrated utility in identifying blood-rich malignancies in breast tissue. We describe the development and characterization of a laser OA imaging system for the prostate (LOIS-P). The system consists of a fiber-coupled Q-switched laser operating at 757 nm, a commercial 128-channel ultrasonic probe, a digital signal processor, and software that, uses the filtered radial back-projection algorithm for image reconstruction. The system is used to reconstruct OA images of a blood-rich lesion in-duced in vivo in a canine prostate. OA images obtained in vivo are compared to images acquired using ultrasound, the current gold stan-dard for guiding biopsy of the prostate. Although key structural fea-tures such as the urethra could be identified with both imaging tech-niques, a bloody lesion representing a highly vascularized tumor could only be clearly identified in OA images. The advantages and limitations of both forward and backward illumination modes are also evaluated by collecting OA images of phantoms simulating blood ves-sels within tissue. System resolution is estimated to be 0.2 mm in the radial direction of the acoustic array. The minimum detectable pres-sure signal is 1.83 Pa. Our results encourage further development toward a dual-modality OA/ultrasonic system for prostate imaging and image-guided biopsy.

KW - Image reconstruction

KW - Optoacoustic tomography

KW - Prostate cancer

KW - Tran-srectal ultrasound imaging

KW - Tumor imaging

UR - http://www.scopus.com/inward/record.url?scp=77949521279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949521279&partnerID=8YFLogxK

U2 - 10.1117/1.3333548

DO - 10.1117/1.3333548

M3 - Article

VL - 15

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 2

M1 - 021310

ER -