Optoacoustic mapping of cerebral blood oxygenation in humans

Yuriy Petrov, Donald Prough, Irene Y. Petrov, Carol Richardson, Rafael Fonseca, Claudia S. Robertson, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Noninvasive, transcranial mapping, monitoring, and imaging are highly important for detection and management of cerebral abnormalities and neuroscience research. Mapping, imaging, and monitoring of cerebral blood oxygenation are necessary for diagnostics and management of patients with traumatic brain injury, stroke, and other neurological conditions. We proposed to use optoacoustic technology for noninvasive, transcranial monitoring and imaging. In this work, we developed optoacoustic systems for mapping of cerebral blood oxygenation in humans and tested them in adults and neonates. The systems provide noninvasive, transcranial optoacoustic measurements in the transmission (forward) and reflection (backward) modes in the near infrared spectral range. Novel, ultra-sensitive probes were built for detection of optoacoustic signals and measurement of blood oxygenation in neonates and adults. Cerebral oxygenation was measured at different lateral sites from the superior sagittal sinus (SSS), a large central cerebral vein, located immediately beneath the midline of the human skull. In neonates, cerebral oxygenation was measured through open anterior and posterior fontanelles. Optoacoustic signal detection at different locations allowed for mapping of cerebral blood oxygenation. Our future studies will be focused on 3D mapping of cerebral blood oxygenation.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound: Imaging and Sensing 2017
PublisherSPIE
Volume10064
ISBN (Electronic)9781510605695
DOIs
StatePublished - 2017
EventPhotons Plus Ultrasound: Imaging and Sensing 2017 - San Francisco, United States
Duration: Jan 29 2017Feb 1 2017

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2017
CountryUnited States
CitySan Francisco
Period1/29/172/1/17

Fingerprint

Oxygenation
Photoacoustic effect
oxygenation
blood
Blood
Cranial Fontanelles
Newborn Infant
Photoacoustic Techniques
Imaging techniques
Superior Sagittal Sinus
Cerebral Veins
Monitoring
Neurosciences
brain damage
Skull
neurology
sinuses
skull
signal detection
Signal detection

Keywords

  • Cerebral
  • Imaging
  • Mapping
  • Monitoring
  • Optoacoustic
  • Oxygenation
  • Photoacoustic
  • Venous

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Petrov, Y., Prough, D., Petrov, I. Y., Richardson, C., Fonseca, R., Robertson, C. S., & Esenaliev, R. (2017). Optoacoustic mapping of cerebral blood oxygenation in humans. In Photons Plus Ultrasound: Imaging and Sensing 2017 (Vol. 10064). [100640A] SPIE. https://doi.org/10.1117/12.2256167

Optoacoustic mapping of cerebral blood oxygenation in humans. / Petrov, Yuriy; Prough, Donald; Petrov, Irene Y.; Richardson, Carol; Fonseca, Rafael; Robertson, Claudia S.; Esenaliev, Rinat.

Photons Plus Ultrasound: Imaging and Sensing 2017. Vol. 10064 SPIE, 2017. 100640A.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Petrov, Y, Prough, D, Petrov, IY, Richardson, C, Fonseca, R, Robertson, CS & Esenaliev, R 2017, Optoacoustic mapping of cerebral blood oxygenation in humans. in Photons Plus Ultrasound: Imaging and Sensing 2017. vol. 10064, 100640A, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2017, San Francisco, United States, 1/29/17. https://doi.org/10.1117/12.2256167
Petrov Y, Prough D, Petrov IY, Richardson C, Fonseca R, Robertson CS et al. Optoacoustic mapping of cerebral blood oxygenation in humans. In Photons Plus Ultrasound: Imaging and Sensing 2017. Vol. 10064. SPIE. 2017. 100640A https://doi.org/10.1117/12.2256167
Petrov, Yuriy ; Prough, Donald ; Petrov, Irene Y. ; Richardson, Carol ; Fonseca, Rafael ; Robertson, Claudia S. ; Esenaliev, Rinat. / Optoacoustic mapping of cerebral blood oxygenation in humans. Photons Plus Ultrasound: Imaging and Sensing 2017. Vol. 10064 SPIE, 2017.
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