Optoacoustic measurement of central venous oxygenation for assessment of circulatory shock

Clinical study in cardiac surgery patients

Irene Y. Petrov, Donald Prough, Michael Kinsky, Yuriy Petrov, Andrey Petrov, S. Nan Henkel, Roger Seeton, Michael G. Salter, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

Circulatory shock is a dangerous medical condition, in which blood flow cannot provide the necessary amount of oxygen to organs and tissues. Currently, its diagnosis and therapy decisions are based on hemodynamic parameters (heart rate, blood pressure, blood gases) and mental status of a patient, which all have low specificity. Measurement of mixed or central venous blood oxygenation via catheters is more reliable, but highly invasive and associated with complications. Our previous studies in healthy volunteers demonstrated that optoacoustic systems provide non-invasive measurement of blood oxygenation in specific vessels, including central veins. Here we report our first results of a clinical study in coronary artery bypass graft (CABG) surgery patients. We used a medical-grade OPO-based optoacoustic system developed in our laboratory to measure in real time blood oxygenation in the internal jugular vein (IJV) of these patients. A clinical ultrasound imaging system (GE Vivid e) was used for IJV localization. Catheters were placed in the IJV as part of routine care and blood samples taken via the catheters were processed with a CO-oximeter. The optoacoustic oxygenation data were compared to the CO-oximeter readings. Good correlation between the noninvasive and invasive measurements was obtained. The results of these studies suggest that the optoacoustic system can provide accurate, noninvasive measurements of central venous oxygenation that can be used for patients with circulatory shock.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8943
ISBN (Print)9780819498564
DOIs
StatePublished - 2014
EventPhotons Plus Ultrasound: Imaging and Sensing 2014 - San Francisco, CA, United States
Duration: Feb 2 2014Feb 5 2014

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2014
CountryUnited States
CitySan Francisco, CA
Period2/2/142/5/14

Fingerprint

Oxygenation
Photoacoustic effect
oxygenation
surgery
Surgery
Thoracic Surgery
blood
Shock
Blood
veins
shock
Catheters
Jugular Veins
Oximeters
Carbon Monoxide
blood pressure
heart rate
hemodynamics
bypasses
blood flow

Keywords

  • Central venous oxygenation
  • Circulatory shock
  • Noninvasive monitoring
  • Optoacoustics
  • Ultrasound imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Petrov, I. Y., Prough, D., Kinsky, M., Petrov, Y., Petrov, A., Henkel, S. N., ... Esenaliev, R. (2014). Optoacoustic measurement of central venous oxygenation for assessment of circulatory shock: Clinical study in cardiac surgery patients. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8943). [89430Y] SPIE. https://doi.org/10.1117/12.2045356

Optoacoustic measurement of central venous oxygenation for assessment of circulatory shock : Clinical study in cardiac surgery patients. / Petrov, Irene Y.; Prough, Donald; Kinsky, Michael; Petrov, Yuriy; Petrov, Andrey; Henkel, S. Nan; Seeton, Roger; Salter, Michael G.; Esenaliev, Rinat.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8943 SPIE, 2014. 89430Y.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Petrov, IY, Prough, D, Kinsky, M, Petrov, Y, Petrov, A, Henkel, SN, Seeton, R, Salter, MG & Esenaliev, R 2014, Optoacoustic measurement of central venous oxygenation for assessment of circulatory shock: Clinical study in cardiac surgery patients. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8943, 89430Y, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2014, San Francisco, CA, United States, 2/2/14. https://doi.org/10.1117/12.2045356
Petrov IY, Prough D, Kinsky M, Petrov Y, Petrov A, Henkel SN et al. Optoacoustic measurement of central venous oxygenation for assessment of circulatory shock: Clinical study in cardiac surgery patients. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8943. SPIE. 2014. 89430Y https://doi.org/10.1117/12.2045356
Petrov, Irene Y. ; Prough, Donald ; Kinsky, Michael ; Petrov, Yuriy ; Petrov, Andrey ; Henkel, S. Nan ; Seeton, Roger ; Salter, Michael G. ; Esenaliev, Rinat. / Optoacoustic measurement of central venous oxygenation for assessment of circulatory shock : Clinical study in cardiac surgery patients. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8943 SPIE, 2014.
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