Optoacoustic measurements of human placenta and umbilical blood oxygenation

Tatiana Nanovskaya, I. Y. Petrov, Y. Petrov, S. L. Patrikeeva, Mahmoud Ahmed, Gary Hankins, Donald Prough, Rinat Esenaliev

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    Adequate oxygenation is essential for normal embryogenesis and fetal growth. Perturbations in the intrauterine oxidative environment during pregnancy are associated with several pathophysiological disorders such as pregnancy loss, preeclampsia, and intrauterine growth restriction. We proposed to use optoacoustic technology for monitoring placental and fetal umbilical blood oxygenation. In this work, we studied optoacoustic monitoring of oxygenation in placenta and umbilical cord blood ex vivo using technique of placenta perfusion. We used a medical grade, nearinfrared, tunable, optoacoustic system developed and built for oxygenation monitoring in blood vessels and in tissues. First, we calibrated the system for cord blood oxygenation measurements by using a CO-Oximeter (gold standard). Then we performed validation in cord blood circulating through the catheters localized on the fetal side of an isolated placental lobule. Finally, the oxygenation measurements were performed in the perfused placental tissue. To increase or decrease blood oxygenation, we used infusion of a gas mixture of 95% O2 + 5% CO2 and 95% N2 + 5% CO2, respectively. In placental tissue, up to four cycles of changes in oxygenation were performed. The optoacoustically measured oxygenation in circulating cord blood and in placental lobule closely correlated with the actual oxygenation data measured by CO-Oximeter. We plan to further test the placental and cord blood oxygenation monitoring with optoacoustics in animal and clinical studies.

    Original languageEnglish (US)
    Title of host publicationPhotons Plus Ultrasound: Imaging and Sensing 2016
    PublisherSPIE
    Volume9708
    ISBN (Electronic)9781628419429
    DOIs
    StatePublished - 2016
    EventPhotons Plus Ultrasound: Imaging and Sensing 2016 - San Francisco, United States
    Duration: Feb 14 2016Feb 17 2016

    Other

    OtherPhotons Plus Ultrasound: Imaging and Sensing 2016
    CountryUnited States
    CitySan Francisco
    Period2/14/162/17/16

    Fingerprint

    Umbilicus
    Oxygenation
    Photoacoustic effect
    oxygenation
    Fetal Blood
    Placenta
    blood
    Blood
    Carbon Monoxide
    Photoacoustic Techniques
    Oximeters
    Pregnancy
    Monitoring
    pregnancy
    Tissue
    Fetal Development
    Pre-Eclampsia
    Embryonic Development
    Blood Vessels
    Catheters

    Keywords

    • fetus
    • hypoxia
    • noninvasive monitoring
    • Optoacoustic
    • oxygenation
    • placenta

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics
    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Radiology Nuclear Medicine and imaging

    Cite this

    Nanovskaya, T., Petrov, I. Y., Petrov, Y., Patrikeeva, S. L., Ahmed, M., Hankins, G., ... Esenaliev, R. (2016). Optoacoustic measurements of human placenta and umbilical blood oxygenation. In Photons Plus Ultrasound: Imaging and Sensing 2016 (Vol. 9708). [97080N] SPIE. https://doi.org/10.1117/12.2218923

    Optoacoustic measurements of human placenta and umbilical blood oxygenation. / Nanovskaya, Tatiana; Petrov, I. Y.; Petrov, Y.; Patrikeeva, S. L.; Ahmed, Mahmoud; Hankins, Gary; Prough, Donald; Esenaliev, Rinat.

    Photons Plus Ultrasound: Imaging and Sensing 2016. Vol. 9708 SPIE, 2016. 97080N.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Nanovskaya, T, Petrov, IY, Petrov, Y, Patrikeeva, SL, Ahmed, M, Hankins, G, Prough, D & Esenaliev, R 2016, Optoacoustic measurements of human placenta and umbilical blood oxygenation. in Photons Plus Ultrasound: Imaging and Sensing 2016. vol. 9708, 97080N, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2016, San Francisco, United States, 2/14/16. https://doi.org/10.1117/12.2218923
    Nanovskaya T, Petrov IY, Petrov Y, Patrikeeva SL, Ahmed M, Hankins G et al. Optoacoustic measurements of human placenta and umbilical blood oxygenation. In Photons Plus Ultrasound: Imaging and Sensing 2016. Vol. 9708. SPIE. 2016. 97080N https://doi.org/10.1117/12.2218923
    Nanovskaya, Tatiana ; Petrov, I. Y. ; Petrov, Y. ; Patrikeeva, S. L. ; Ahmed, Mahmoud ; Hankins, Gary ; Prough, Donald ; Esenaliev, Rinat. / Optoacoustic measurements of human placenta and umbilical blood oxygenation. Photons Plus Ultrasound: Imaging and Sensing 2016. Vol. 9708 SPIE, 2016.
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