Optoacoustic monitoring of blood hemoglobin concentration: A pilot clinical study

Irina Y. Petrova; Rinat O. Esenaliev; Yuriy Y. Petrov; Hans Peter F. Brecht; Christer H. Svensen; Joel Olsson; Donald Deyo; Donald S. Prough

doi:10.1364/OL.30.001677

Optoacoustic monitoring of blood hemoglobin concentration: A pilot clinical study

Irina Y. Petrova, Rinat O. Esenaliev, Yuriy Y. Petrov, Hans Peter F. Brecht, Christer H. Svensen, Joel Olsson, Donald Deyo, Donald S. Prough

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

The optoacoustic technique is noninvasive, has high spatial resolution, and potentially can be used to measure the total hemoglobin concentration ([THb]) continuously and accurately. We performed in vitro measurements in blood and in vivo tests in healthy volunteers. Our clinical protocol included rapid infusion of intravenous saline to simulate rapid change in the [THb] during fluid therapy or surgery. Optoacoustic measurements were made from the wrist area overlying the radial artery for more than 1 h. The amplitude of the optoacoustic signal generated in the radial artery closely followed the [THb] measured directly in concurrently collected blood samples.

Original language	English (US)
Pages (from-to)	1677-1679
Number of pages	3
Journal	Optics Letters
Volume	30
Issue number	13
DOIs	https://doi.org/10.1364/OL.30.001677
State	Published - Jul 1 2005

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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abstract = "The optoacoustic technique is noninvasive, has high spatial resolution, and potentially can be used to measure the total hemoglobin concentration ([THb]) continuously and accurately. We performed in vitro measurements in blood and in vivo tests in healthy volunteers. Our clinical protocol included rapid infusion of intravenous saline to simulate rapid change in the [THb] during fluid therapy or surgery. Optoacoustic measurements were made from the wrist area overlying the radial artery for more than 1 h. The amplitude of the optoacoustic signal generated in the radial artery closely followed the [THb] measured directly in concurrently collected blood samples.",

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AU - Petrova, Irina Y.

AU - Esenaliev, Rinat O.

AU - Petrov, Yuriy Y.

AU - Brecht, Hans Peter F.

AU - Svensen, Christer H.

AU - Olsson, Joel

AU - Deyo, Donald

AU - Prough, Donald S.

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AB - The optoacoustic technique is noninvasive, has high spatial resolution, and potentially can be used to measure the total hemoglobin concentration ([THb]) continuously and accurately. We performed in vitro measurements in blood and in vivo tests in healthy volunteers. Our clinical protocol included rapid infusion of intravenous saline to simulate rapid change in the [THb] during fluid therapy or surgery. Optoacoustic measurements were made from the wrist area overlying the radial artery for more than 1 h. The amplitude of the optoacoustic signal generated in the radial artery closely followed the [THb] measured directly in concurrently collected blood samples.

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Optoacoustic monitoring of blood hemoglobin concentration: A pilot clinical study

Abstract

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