Optoacoustic monitoring of blood hemoglobin concentration: A pilot clinical study

Irina Y. Petrova, Rinat O. Esenaliev, Yuriy Y. Petrov, Hans Peter F. Brecht, Christer H. Svensen, Joel Olsson, Donald Deyo, Donald S. Prough

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


The optoacoustic technique is noninvasive, has high spatial resolution, and potentially can be used to measure the total hemoglobin concentration ([THb]) continuously and accurately. We performed in vitro measurements in blood and in vivo tests in healthy volunteers. Our clinical protocol included rapid infusion of intravenous saline to simulate rapid change in the [THb] during fluid therapy or surgery. Optoacoustic measurements were made from the wrist area overlying the radial artery for more than 1 h. The amplitude of the optoacoustic signal generated in the radial artery closely followed the [THb] measured directly in concurrently collected blood samples.

Original languageEnglish (US)
Pages (from-to)1677-1679
Number of pages3
JournalOptics Letters
Issue number13
StatePublished - Jul 1 2005

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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