Optoacoustic monitoring of cerebral venous blood oxygenation through extracerebral blood

I. Y. Petrov, Y. Petrov, Donald Prough, D. J. Deyo, I. Cicenaite, Rinat Esenaliev

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

There is strong clinical evidence that controlling cerebral venous oxygenation (oxyhemoglobin saturation) is critically important for patients with severe traumatic brain injury as well as for patients undergoing cardiac surgery. However, the only available method for cerebral venous blood oxygenation monitoring is invasive and requires catheterization of the internal jugular vein. We designed and built a novel optoacoustic monitor of cerebral venous oxygenation as measured in the superior sagittal sinus (SSS), the large midline cerebral vein. To the best of our knowledge, optical monitoring of cerebral venous blood oxygenation through overlying extracerebral blood is reported for the first time in this paper. The system was capable of detecting SSS signals in vivo at 700, 800, and 1064 nm through the thick (5-6 mm) sheep skull containing the circulating blood. The high (submillimeter) in-depth resolution of the system provided identification of the SSS peaks in the optoacoustic signals. The SSS peak amplitude closely followed the actual SSS blood oxygenation measured invasively using catheterization, blood sampling, and "gold standard" CO-Oximetry. Our data indicate the system may provide accurate measurement of the SSS blood oxygenation in patients with extracerebral blood over the SSS.

Original languageEnglish (US)
Pages (from-to)125-136
Number of pages12
JournalBiomedical Optics Express
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2012

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Superior Sagittal Sinus
sinuses
oxygenation
blood
catheterization
veins
Catheterization
oximetry
brain damage
Cerebral Veins
oxyhemoglobin
sheep
Oxyhemoglobins
skull
Oximetry
system identification
Jugular Veins
Carbon Monoxide
Information Systems
Skull

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Optoacoustic monitoring of cerebral venous blood oxygenation through extracerebral blood. / Petrov, I. Y.; Petrov, Y.; Prough, Donald; Deyo, D. J.; Cicenaite, I.; Esenaliev, Rinat.

In: Biomedical Optics Express, Vol. 3, No. 1, 01.01.2012, p. 125-136.

Research output: Contribution to journalArticle

Petrov, I. Y. ; Petrov, Y. ; Prough, Donald ; Deyo, D. J. ; Cicenaite, I. ; Esenaliev, Rinat. / Optoacoustic monitoring of cerebral venous blood oxygenation through extracerebral blood. In: Biomedical Optics Express. 2012 ; Vol. 3, No. 1. pp. 125-136.
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