TY - JOUR
T1 - Optoacoustic monitoring of physiologic variables
AU - Esenaliev, Rinat O.
N1 - Funding Information:
The author thanks Drs. Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, Claudia S. Robertson, C. Joan Richardson, other members of the Department of Anesthesiology, Department of Pediatrics and Neonatal Intensive Care Unit at UTMB, and the Department of Neurosurgery and Neurointensive Care Unit of Baylor College of Medicine. Grant support: NIH grants #R01EB00763 and #U54EB007954 from the National Institute of Biomedical Imaging and Bioengineering, #R01NS044345 and #R21NS40531 from the National Institute of Neurological Disorders and Stroke, #R41HD076568 and #R43HD075551 form the Eunice Kennedy Shriver National Institute of Child Health & Human Development, and #R41HL10309501 from the National Heart, Lung and Blood Institute, contracts from Noninvasix, Inc., the Texas Emerging Technology Fund, and the Moody Center for Brain and Spinal Cord Injury Research/Mission Connect of UTMB. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIBIB or NIH.
Publisher Copyright:
© 2017 Esenaliev.
PY - 2017/12/12
Y1 - 2017/12/12
N2 - Optoacoustic (photoacoustic) technique is a novel diagnostic platform that can be used for noninvasive measurements of physiologic variables, functional imaging, and hemodynamic monitoring. This technique is based on generation and time-resolved detection of optoacoustic (thermoelastic) waves generated in tissue by short optical pulses. This provides probing of tissues and individual blood vessels with high optical contrast and ultrasound spatial resolution. Because the optoacoustic waves carry information on tissue optical and thermophysical properties, detection, and analysis of the optoacoustic waves allow for measurements of physiologic variables with high accuracy and specificity. We proposed to use the optoacoustic technique for monitoring of a number of important physiologic variables including temperature, thermal coagulation, freezing, concentration of molecular dyes, nanoparticles, oxygenation, and hemoglobin concentration. In this review we present origin of contrast and high spatial resolution in these measurements performed with optoacoustic systems developed and built by our group. We summarize data obtained in vitro, in experimental animals, and in humans on monitoring of these physiologic variables. Our data indicate that the optoacoustic technology may be used for monitoring of cerebral blood oxygenation in patients with traumatic brain injury and in neonatal patients, central venous oxygenation monitoring, total hemoglobin concentration monitoring, hematoma detection and characterization, monitoring of temperature, and coagulation and freezing boundaries during thermotherapy.
AB - Optoacoustic (photoacoustic) technique is a novel diagnostic platform that can be used for noninvasive measurements of physiologic variables, functional imaging, and hemodynamic monitoring. This technique is based on generation and time-resolved detection of optoacoustic (thermoelastic) waves generated in tissue by short optical pulses. This provides probing of tissues and individual blood vessels with high optical contrast and ultrasound spatial resolution. Because the optoacoustic waves carry information on tissue optical and thermophysical properties, detection, and analysis of the optoacoustic waves allow for measurements of physiologic variables with high accuracy and specificity. We proposed to use the optoacoustic technique for monitoring of a number of important physiologic variables including temperature, thermal coagulation, freezing, concentration of molecular dyes, nanoparticles, oxygenation, and hemoglobin concentration. In this review we present origin of contrast and high spatial resolution in these measurements performed with optoacoustic systems developed and built by our group. We summarize data obtained in vitro, in experimental animals, and in humans on monitoring of these physiologic variables. Our data indicate that the optoacoustic technology may be used for monitoring of cerebral blood oxygenation in patients with traumatic brain injury and in neonatal patients, central venous oxygenation monitoring, total hemoglobin concentration monitoring, hematoma detection and characterization, monitoring of temperature, and coagulation and freezing boundaries during thermotherapy.
KW - Imaging
KW - Monitoring
KW - Optoacoustic
KW - Photoacoustic
KW - Physiologic
KW - Sensing
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U2 - 10.3389/fphys.2017.01030
DO - 10.3389/fphys.2017.01030
M3 - Short survey
AN - SCOPUS:85037851335
SN - 1664-042X
VL - 8
JO - Frontiers in Physiology
JF - Frontiers in Physiology
IS - DEC
M1 - 1030
ER -