Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice

Shuhui Wang, Thomas Weite, Hao Fang, Gwong Jen J Chang, Willi K. Born, Rebecca L. O'Brien, Buxiang Sun, Hajime Fujii, Ken Ichi Kosuna, Tian Wang

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

West Nile virus (WNV) poses a serious threat to public health, especially to the elderly and the immuno-compromised. Neither vaccines nor treatments are available for humans. Active hexose correlated compound (AHCC) is an extract of Lentinula edodes of the Basidiomycete family of fungi rich in α-glucans. In this study, we evaluated the effect of AHCC on host susceptibility in the murine model of WNV infection. Mice orally administered with AHCC (600 mg/kg) every other day for 1 wk before and at d 1 and 3 postinfection were assessed using viremia levels, survival rate, and protective immunity. AHCC administration in young (6- to 8-wk-old) mice attenuated viremia and mortality following lethal WNV infection. WNV-specific IgM and IgG production and γδ T cell expansion were also enhanced in these mice. Aged (21- to 22-mo-old) mice were more susceptible to WNV infection than young mice, partially due to the dysfunction of γδ T cell subsets. AHCC administration in aged mice enhanced the protective Vγ1 + T cell response as well as WNV-specific IgG but not IgM antibodies production. AHCC administration in aged mice attenuated viremia levels but led to no difference in mortality rate. Overall, our data suggests that AHCC enhances protective host immune responses against WNV infection in young and aged mice. Dietary supplementation with AHCC may be potentially immunotherapeutic for WNV-susceptible populations.

Original languageEnglish (US)
Pages (from-to)598-602
Number of pages5
JournalJournal of Nutrition
Volume139
Issue number3
DOIs
StatePublished - Mar 2009

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West Nile virus
Encephalitis
Oral Administration
Virus Diseases
Viremia
Immunoglobulin M
Immunoglobulin G
Shiitake Mushrooms
T-Lymphocytes
Basidiomycota
Glucans
Mortality
Active Hexose Correlated Compound
T-Lymphocyte Subsets
Dietary Supplements
Antibody Formation
Immunity
Fungi
Vaccines
Survival Rate

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. / Wang, Shuhui; Weite, Thomas; Fang, Hao; Chang, Gwong Jen J; Born, Willi K.; O'Brien, Rebecca L.; Sun, Buxiang; Fujii, Hajime; Kosuna, Ken Ichi; Wang, Tian.

In: Journal of Nutrition, Vol. 139, No. 3, 03.2009, p. 598-602.

Research output: Contribution to journalArticle

Wang, S, Weite, T, Fang, H, Chang, GJJ, Born, WK, O'Brien, RL, Sun, B, Fujii, H, Kosuna, KI & Wang, T 2009, 'Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice', Journal of Nutrition, vol. 139, no. 3, pp. 598-602. https://doi.org/10.3945/jn.108.100297
Wang, Shuhui ; Weite, Thomas ; Fang, Hao ; Chang, Gwong Jen J ; Born, Willi K. ; O'Brien, Rebecca L. ; Sun, Buxiang ; Fujii, Hajime ; Kosuna, Ken Ichi ; Wang, Tian. / Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. In: Journal of Nutrition. 2009 ; Vol. 139, No. 3. pp. 598-602.
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