Oral administration of human or murine interferon alpha suppresses relapses and modifies adoptive transfer in experimental autoimmune encephalomyelitis

Staley A. Brod, Mohammed Khan, Ronald H. Kerman, Miguel Pappolla

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Chronic relapsing experimental autoimmune encephalitis (CR-EAE) is an inflammatory process of the central nervous system (CNS) that closely resembles the human disease multiple sclerosis (MS). EAE was induced in SJL/J mice and following recovery from the initial attack, animals were fed varying doses of human or murine interferon alpha (IFN-α), or mock IFN three times per week. After relapse, concanavalin A-activated spleen cells were transferred adoptively from orally fed animals into recipient animals. Oral administration of human or murine IFN-α suppressed relapse in actively immunized animals, modified adoptive transfer of EAE, and decreased mitogen/antigen proliferation and IFN-γ secretion in both donors and recipients. IFN-α acts orally by modifying the encephalitogenicity of donor spleen T cells.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalJournal of Neuroimmunology
Volume58
Issue number1
DOIs
StatePublished - Apr 1995
Externally publishedYes

Keywords

  • Adoptive transfer
  • Experimental autoimmune encephalomyelitis
  • Interferon-α
  • Interferon-γ
  • Oral feeding

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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