Oral administration of human or murine interferon alpha suppresses relapses and modifies adoptive transfer in experimental autoimmune encephalomyelitis

Staley A. Brod, Mohammed Khan, Ronald H. Kerman, Miguel Pappolla

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Chronic relapsing experimental autoimmune encephalitis (CR-EAE) is an inflammatory process of the central nervous system (CNS) that closely resembles the human disease multiple sclerosis (MS). EAE was induced in SJL/J mice and following recovery from the initial attack, animals were fed varying doses of human or murine interferon alpha (IFN-α), or mock IFN three times per week. After relapse, concanavalin A-activated spleen cells were transferred adoptively from orally fed animals into recipient animals. Oral administration of human or murine IFN-α suppressed relapse in actively immunized animals, modified adoptive transfer of EAE, and decreased mitogen/antigen proliferation and IFN-γ secretion in both donors and recipients. IFN-α acts orally by modifying the encephalitogenicity of donor spleen T cells.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalJournal of Neuroimmunology
Volume58
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Autoimmune Experimental Encephalomyelitis
Adoptive Transfer
Interferon-alpha
Oral Administration
Recurrence
Spleen
Concanavalin A
Mitogens
Multiple Sclerosis
Central Nervous System
T-Lymphocytes
Antigens

Keywords

  • Adoptive transfer
  • Experimental autoimmune encephalomyelitis
  • Interferon-α
  • Interferon-γ
  • Oral feeding

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

Oral administration of human or murine interferon alpha suppresses relapses and modifies adoptive transfer in experimental autoimmune encephalomyelitis. / Brod, Staley A.; Khan, Mohammed; Kerman, Ronald H.; Pappolla, Miguel.

In: Journal of Neuroimmunology, Vol. 58, No. 1, 1995, p. 61-69.

Research output: Contribution to journalArticle

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