Oral administration of unsaturated fatty acids: Effects on human peripheral blood T lymphocyte proliferation

Ronald G. Rossetti, Christina M. Seiler, Pamela DeLuca, Michael Laposata, Robert B. Zurier

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Oils enriched in certain polyunsaturated fatty acids suppress joint pain and swelling in rheumatoid arthritis (RA) patients. Because T lymphocyte activation is important to propagation of joint tissue injury in patients with RA, we examined the effects of fatty acids administered by mouth in vivo on proliferation of human lymphocytes activated through the T cell receptor complex. T cell proliferation was reduced after oral administration of 2.4 g gammalinolenic acid in capsules of borage seed oil. Oral administration of oils enriched in linoleic acid, the parent n-6 fatty acid, and alpha linolenic acid, the parent n-3 fatty acid, did not influence growth of stimulated cells. Fatty acid analyses indicated that suppression of lymphocyte proliferation after gammalinolenic acid administration was associated with increased plasma and peripheral blood mononuclear cell concentrations of gammalinolenic acid and dihomogammalinolenic acid.

Original languageEnglish (US)
Pages (from-to)438-443
Number of pages6
JournalJournal of Leukocyte Biology
Volume62
Issue number4
StatePublished - Oct 1 1997
Externally publishedYes

Keywords

  • Gammalinolenic acid
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Fingerprint Dive into the research topics of 'Oral administration of unsaturated fatty acids: Effects on human peripheral blood T lymphocyte proliferation'. Together they form a unique fingerprint.

  • Cite this