Oral administration of unsaturated fatty acids

Effects on human peripheral blood T lymphocyte proliferation

Ronald G. Rossetti, Christina M. Seiler, Pamela DeLuca, Michael Laposata, Robert B. Zurier

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Oils enriched in certain polyunsaturated fatty acids suppress joint pain and swelling in rheumatoid arthritis (RA) patients. Because T lymphocyte activation is important to propagation of joint tissue injury in patients with RA, we examined the effects of fatty acids administered by mouth in vivo on proliferation of human lymphocytes activated through the T cell receptor complex. T cell proliferation was reduced after oral administration of 2.4 g gammalinolenic acid in capsules of borage seed oil. Oral administration of oils enriched in linoleic acid, the parent n-6 fatty acid, and alpha linolenic acid, the parent n-3 fatty acid, did not influence growth of stimulated cells. Fatty acid analyses indicated that suppression of lymphocyte proliferation after gammalinolenic acid administration was associated with increased plasma and peripheral blood mononuclear cell concentrations of gammalinolenic acid and dihomogammalinolenic acid.

Original languageEnglish (US)
Pages (from-to)438-443
Number of pages6
JournalJournal of Leukocyte Biology
Volume62
Issue number4
StatePublished - Oct 1997
Externally publishedYes

Fingerprint

Unsaturated Fatty Acids
Oral Administration
Fatty Acids
T-Lymphocytes
Acids
Rheumatoid Arthritis
Oils
8,11,14-Eicosatrienoic Acid
Lymphocytes
alpha-Linolenic Acid
Omega-3 Fatty Acids
Arthralgia
Linoleic Acid
Lymphocyte Activation
T-Cell Antigen Receptor
Capsules
Mouth
Blood Cells
Seeds
Joints

Keywords

  • Gammalinolenic acid
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Cell Biology

Cite this

Oral administration of unsaturated fatty acids : Effects on human peripheral blood T lymphocyte proliferation. / Rossetti, Ronald G.; Seiler, Christina M.; DeLuca, Pamela; Laposata, Michael; Zurier, Robert B.

In: Journal of Leukocyte Biology, Vol. 62, No. 4, 10.1997, p. 438-443.

Research output: Contribution to journalArticle

Rossetti, Ronald G. ; Seiler, Christina M. ; DeLuca, Pamela ; Laposata, Michael ; Zurier, Robert B. / Oral administration of unsaturated fatty acids : Effects on human peripheral blood T lymphocyte proliferation. In: Journal of Leukocyte Biology. 1997 ; Vol. 62, No. 4. pp. 438-443.
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