Oral and Conjunctival Exposure of Nonhuman Primates to Low Doses of Ebola Makona Virus

Chad Mire, Joan B. Geisbert, Krystle N. Agans, Daniel J. Deer, Karla A. Fenton, Thomas Geisbert

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Nonhuman primate (NHP) models of Ebola virus (EBOV) infection primarily use parenteral or aerosol routes of exposure. Uniform lethality can be achieved in these models at low doses of EBOV (≤100 plaque-forming units [PFU]). Here, we exposed NHPs to low doses of EBOV (Makona strain) by the oral or conjunctival routes. Surprisingly, animals exposed to 10 PFU by either route showed no signs of disease. Exposure to 100 PFU resulted in illness and/or lethal infection. These results suggest that these more natural routes require higher doses of EBOV to produce disease or that there may be differences between Makona and historical strains.

Original languageEnglish (US)
Pages (from-to)S263-S267
JournalJournal of Infectious Diseases
Volume214
DOIs
StatePublished - Oct 15 2016

Keywords

  • Ebola virus
  • Nonhuman primate
  • Pathogenesis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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