Oral Glutamine Accelerates Healing of the Small Intestine and Improves Outcome After Whole Abdominal Radiation

Vicki Klimberg, Rabih M. Salloum, Michael Kasper, Donald A. Plumley, David J. Dolson, R. Dean Hautamaki, William R. Mendenhall, Frank C. Bova, Kirby I. Bland, Edward M. Copeland, Wiley W. Souba

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

The healing effects of glutamine given orally for 8 days as a single amino acid nutrient after treatment with whole abdominal radiation (10 Gy) were studied. Rats received isonitrogenous and isovolumic diets containing 3% glutamine or 3% glycine. Control rats were not irradiated but were given identical diets. In irradiated animals, survival was 100% in animals receiving glutamine compared with 45% in animals receiving glycine. Glutamine ingestion diminished bloody diarrhea and the incidence of bowel perforation. Arterial glutamine level was higher in animals receiving glutamine in the diet, as were gut glutamine extraction (35%±8% vs 12%±7%) and intestinal glutaminase activity. These metabolic improvements were associated with a marked increase in villous height, villous number, and the number of mitoses per crypt in rats receiving glutamine. Glutamine was not beneficial in control nonirradiated animals. The data demonstrated that provision of oral glutamine after abdominal radiation supported gut glutamine metabolism, improved mucosal morphometrics, and decreased the morbidity and mortality associated with this abdominal radiation model.

Original languageEnglish (US)
Pages (from-to)1040-1045
Number of pages6
JournalArchives of Surgery
Volume125
Issue number8
DOIs
StatePublished - 1990
Externally publishedYes

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Glutamine
Small Intestine
Radiation
Diet
Glycine
Glutaminase
Radiation Dosage
Mitosis
Diarrhea
Eating
Morbidity
Amino Acids
Food
Mortality
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Oral Glutamine Accelerates Healing of the Small Intestine and Improves Outcome After Whole Abdominal Radiation. / Klimberg, Vicki; Salloum, Rabih M.; Kasper, Michael; Plumley, Donald A.; Dolson, David J.; Hautamaki, R. Dean; Mendenhall, William R.; Bova, Frank C.; Bland, Kirby I.; Copeland, Edward M.; Souba, Wiley W.

In: Archives of Surgery, Vol. 125, No. 8, 1990, p. 1040-1045.

Research output: Contribution to journalArticle

Klimberg, V, Salloum, RM, Kasper, M, Plumley, DA, Dolson, DJ, Hautamaki, RD, Mendenhall, WR, Bova, FC, Bland, KI, Copeland, EM & Souba, WW 1990, 'Oral Glutamine Accelerates Healing of the Small Intestine and Improves Outcome After Whole Abdominal Radiation', Archives of Surgery, vol. 125, no. 8, pp. 1040-1045. https://doi.org/10.1001/archsurg.1990.01410200104017
Klimberg, Vicki ; Salloum, Rabih M. ; Kasper, Michael ; Plumley, Donald A. ; Dolson, David J. ; Hautamaki, R. Dean ; Mendenhall, William R. ; Bova, Frank C. ; Bland, Kirby I. ; Copeland, Edward M. ; Souba, Wiley W. / Oral Glutamine Accelerates Healing of the Small Intestine and Improves Outcome After Whole Abdominal Radiation. In: Archives of Surgery. 1990 ; Vol. 125, No. 8. pp. 1040-1045.
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