Oral glutamine reduces radiation morbidity in breast conservation surgery

Isabel Rubio, Larry J. Suva, Valentina Todorova, Sudeepa Bhattacharyya, Yihong Kaufmann, Anne Maners, Maureen Smith, Vicki Klimberg

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

This study examined the effect of oral glutamine (Gln) on radiation injury in breast cancer patients undergoing radiation therapy. The radiation injury was evaluated using Radiation Therapy Oncology Group (RTOG) scales. Cosmesis was scored. Blood Gln and glutathione (GSH) levels were determined. Serum protein profiling was determined using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). Patients receiving Gln scored significantly better in RTOG score than the patients receiving placebo. Cosmetic scores averaged excellent in the Gln group vs fair to good in the placebo group. Blood Gln and GSH levels were significantly higher in the Gln group vs the placebo group. Serum protein profiling with SELDI-TOF MS identified a novel Gln-responsive protein that showed amino acid similarity with myoglobin. These results suggest that Gln is an effective way to reduce radiation morbidity to breast cancer and is associated with the increased expression of a novel serum protein biomarker.

Original languageEnglish (US)
Pages (from-to)623-630
Number of pages8
JournalJournal of Parenteral and Enteral Nutrition
Volume37
Issue number5
DOIs
StatePublished - Sep 2013
Externally publishedYes

    Fingerprint

Keywords

  • nutrition
  • nutrition support practice
  • research and diseases

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Rubio, I., Suva, L. J., Todorova, V., Bhattacharyya, S., Kaufmann, Y., Maners, A., Smith, M., & Klimberg, V. (2013). Oral glutamine reduces radiation morbidity in breast conservation surgery. Journal of Parenteral and Enteral Nutrition, 37(5), 623-630. https://doi.org/10.1177/0148607112474994