Orchestrating the Dermal/Epidermal Tissue Ratio during Wound Healing by Controlling the Moisture Content

Alexandru Cristian Tuca, Ives Bernardelli de Mattos, Martin Funk, Raimund Winter, Alen Palackic, Florian Groeber-Becker, Daniel Kruse, Fabian Kukla, Thomas Lemarchand, Lars Peter Kamolz

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A balanced and moist wound environment and surface increases the effect of various growth factors, cytokines, and chemokines, stimulating cell growth and wound healing. Considering this fact, we tested in vitro and in vivo water evaporation rates from the cellulose dressing epicitehydro when combined with different secondary dressings as well as the resulting wound healing efficacy in a porcine donor site model. The aim of this study was to evaluate how the different rates of water evaporation affected wound healing efficacy. To this end, epicitehydro primary dressing, in combination with different secondary dressing materials (cotton gauze, JELONET, AQUACEL® Extra ™, and OPSITE Flexifix), was placed on 3 × 3 cm-sized dermatome wounds with a depth of 1.2 mm on the flanks of domestic pigs. The healing process was analyzed histologically and quantified by morphometry. High water evaporation rates by using the correct secondary dressing, such as cotton gauze, favored a better re-epithelialization in comparison with the low water evaporation resulting from an occlusive secondary dressing, which favored the formation of a new and intact dermal tissue that nearly fully replaced all the dermis that was removed during wounding. This newly available evidence may be of great benefit to clinical wound management.

Original languageEnglish (US)
Article number1286
Issue number6
StatePublished - Jun 2022


  • bacterial cellulose dressing
  • in vivo experiments
  • moisture balance
  • secondary wound dressing
  • wound healing

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Biochemistry, Genetics and Molecular Biology


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