Organization of calcitonin gene-related peptide-immunoreactive terminals in the primate dorsal horn

S. M. Carlton, D. L. McNeill, K. Chung, R. E. Coggeshall

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The present paper is concerned with the arrangement of axons and synaptic terminals immunostained for calcitonin gene-related peptide (CGRP), a primary afferent marker, in the primate (Macaca fascicularis) dorsal horn. The CGRP axons and terminals are uniformly distributed in laminae I and II outer (o) but they are concentrated laterally and distributed intermittently in the reticulated region of lamina V. A prominent bundle of labeled axons is seen in the sacral cord dorsal to the central canal. Emphasis is given to the relation of CGRP-immunoreactive terminals to other terminals, both labeled and unlabeled, in laminae I and IIo. In this regard, adjacent CGRP-immunoreactive terminals are often united by puncta adhaerentia. Of particular interest is the observation that CGRP-immunoreactive terminals can be found presynaptic to other terminals which sometimes resemble central primary afferent endings. In addition CGRP-immunoreactive terminals end on other CGRP terminals. Both findings suggest that primary afferent terminals interact synaptically with other primary afferent terminals.

Original languageEnglish (US)
Pages (from-to)527-536
Number of pages10
JournalJournal of Comparative Neurology
Volume276
Issue number4
StatePublished - 1988

Fingerprint

Calcitonin Gene-Related Peptide
Primates
Presynaptic Terminals
Substantia Gelatinosa
Macaca fascicularis
Spinal Cord Dorsal Horn
Axons
Spinal Cord

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Carlton, S. M., McNeill, D. L., Chung, K., & Coggeshall, R. E. (1988). Organization of calcitonin gene-related peptide-immunoreactive terminals in the primate dorsal horn. Journal of Comparative Neurology, 276(4), 527-536.

Organization of calcitonin gene-related peptide-immunoreactive terminals in the primate dorsal horn. / Carlton, S. M.; McNeill, D. L.; Chung, K.; Coggeshall, R. E.

In: Journal of Comparative Neurology, Vol. 276, No. 4, 1988, p. 527-536.

Research output: Contribution to journalArticle

Carlton, SM, McNeill, DL, Chung, K & Coggeshall, RE 1988, 'Organization of calcitonin gene-related peptide-immunoreactive terminals in the primate dorsal horn', Journal of Comparative Neurology, vol. 276, no. 4, pp. 527-536.
Carlton, S. M. ; McNeill, D. L. ; Chung, K. ; Coggeshall, R. E. / Organization of calcitonin gene-related peptide-immunoreactive terminals in the primate dorsal horn. In: Journal of Comparative Neurology. 1988 ; Vol. 276, No. 4. pp. 527-536.
@article{b6a1932d71ba4e1d90cf7d7e53e3ce18,
title = "Organization of calcitonin gene-related peptide-immunoreactive terminals in the primate dorsal horn",
abstract = "The present paper is concerned with the arrangement of axons and synaptic terminals immunostained for calcitonin gene-related peptide (CGRP), a primary afferent marker, in the primate (Macaca fascicularis) dorsal horn. The CGRP axons and terminals are uniformly distributed in laminae I and II outer (o) but they are concentrated laterally and distributed intermittently in the reticulated region of lamina V. A prominent bundle of labeled axons is seen in the sacral cord dorsal to the central canal. Emphasis is given to the relation of CGRP-immunoreactive terminals to other terminals, both labeled and unlabeled, in laminae I and IIo. In this regard, adjacent CGRP-immunoreactive terminals are often united by puncta adhaerentia. Of particular interest is the observation that CGRP-immunoreactive terminals can be found presynaptic to other terminals which sometimes resemble central primary afferent endings. In addition CGRP-immunoreactive terminals end on other CGRP terminals. Both findings suggest that primary afferent terminals interact synaptically with other primary afferent terminals.",
author = "Carlton, {S. M.} and McNeill, {D. L.} and K. Chung and Coggeshall, {R. E.}",
year = "1988",
language = "English (US)",
volume = "276",
pages = "527--536",
journal = "Journal of Comparative Neurology",
issn = "0021-9967",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Organization of calcitonin gene-related peptide-immunoreactive terminals in the primate dorsal horn

AU - Carlton, S. M.

AU - McNeill, D. L.

AU - Chung, K.

AU - Coggeshall, R. E.

PY - 1988

Y1 - 1988

N2 - The present paper is concerned with the arrangement of axons and synaptic terminals immunostained for calcitonin gene-related peptide (CGRP), a primary afferent marker, in the primate (Macaca fascicularis) dorsal horn. The CGRP axons and terminals are uniformly distributed in laminae I and II outer (o) but they are concentrated laterally and distributed intermittently in the reticulated region of lamina V. A prominent bundle of labeled axons is seen in the sacral cord dorsal to the central canal. Emphasis is given to the relation of CGRP-immunoreactive terminals to other terminals, both labeled and unlabeled, in laminae I and IIo. In this regard, adjacent CGRP-immunoreactive terminals are often united by puncta adhaerentia. Of particular interest is the observation that CGRP-immunoreactive terminals can be found presynaptic to other terminals which sometimes resemble central primary afferent endings. In addition CGRP-immunoreactive terminals end on other CGRP terminals. Both findings suggest that primary afferent terminals interact synaptically with other primary afferent terminals.

AB - The present paper is concerned with the arrangement of axons and synaptic terminals immunostained for calcitonin gene-related peptide (CGRP), a primary afferent marker, in the primate (Macaca fascicularis) dorsal horn. The CGRP axons and terminals are uniformly distributed in laminae I and II outer (o) but they are concentrated laterally and distributed intermittently in the reticulated region of lamina V. A prominent bundle of labeled axons is seen in the sacral cord dorsal to the central canal. Emphasis is given to the relation of CGRP-immunoreactive terminals to other terminals, both labeled and unlabeled, in laminae I and IIo. In this regard, adjacent CGRP-immunoreactive terminals are often united by puncta adhaerentia. Of particular interest is the observation that CGRP-immunoreactive terminals can be found presynaptic to other terminals which sometimes resemble central primary afferent endings. In addition CGRP-immunoreactive terminals end on other CGRP terminals. Both findings suggest that primary afferent terminals interact synaptically with other primary afferent terminals.

UR - http://www.scopus.com/inward/record.url?scp=0023696408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023696408&partnerID=8YFLogxK

M3 - Article

C2 - 3264296

AN - SCOPUS:0023696408

VL - 276

SP - 527

EP - 536

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

IS - 4

ER -