Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

Xi Liu, Jimin Xu, Jia Zhou, Qiang Shen

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Cancer is one of the diseases with high morbidity and mortality on a global scale. Chemotherapy remains the primary treatment option for most cancer patients, including patients with progressive, metastatic, and recurrent diseases. To date, hundreds of chemotherapy drugs are used to treat various cancers, however, the anti-cancer efficacy and outcomes are largely hampered by chemotherapy-associated toxicity and acquired therapeutic resistance. The natural product (NP) oridonin has been extensively studied for its anti-cancer efficacy. More recently, oridonin has been shown to overcome drug resistance through multiple mechanisms, with yet-to-be-defined bona fide targets. Hundreds of oridonin derivative analogs (oridonalogs) have been synthesized and screened for improved potency, bioavailability, and other drug properties. Particularly, many of these oridonalogs have been tested against oridonin for tumor growth inhibition, potential for overcoming therapeutic resistance, and immunity modulation. This concise review seeks to summarize the advances in this field in light of identifying clinical-trial level drug candidates with the promise for treating progressive cancers and reversing chemoresistance.

Original languageEnglish (US)
Pages (from-to)448-462
Number of pages15
JournalGenes and Diseases
Volume8
Issue number4
DOIs
StatePublished - Jul 2021

Keywords

  • Cancer therapy
  • Chemoresistance
  • Derivatives
  • Drug resistance
  • Oridonalogs
  • Oridonin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

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