Origin of arterial wall dissections induced by pulsed excimer and mid-infrared laser ablation in the pig

Ton G. van Leeuwen, Lieselotte van Erven, John H. Meertens, Massoud Motamedi, Mark J. Post, Cornelius Borst

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

To study adjacent tissue damage after delivery of holmium, thulium and excimer laser pulses, porcine thoracic aortas were irradiated in vivo. After 3 days, microscopic analysis of 67 craters produced by all three lasers demonstrated large dissections extending from the craters. The mean diameter of the dissections was smaller for excimer-induced craters (1.38 ± 0.42 mm; n = 22) than for holmium-induced (2.7 ± 0.87 mm; n = 22) and thulium-induced (2.37 ± 0.42 mm; n = 14) craters (p < 0.01 vs. mid-infrared dissections). In addition, microscopic analysis demonstrated necrosis adjacent to the crater. The lateral necrotic zones of the thulium-induced craters were smaller than the holmium- and excimer-induced necrotic zones (p < 0.01). To identify the origin of the excessive tissue tearing, laser-saline and laser-tissue interaction were compared in vitro by time-resoived flash photography, in saline solution, the midinfrared lasers showed bubble formation on a microsecond time scale. The excimer laser produced similar bubbles in the vicinity of tissue. For all three lasers, elevation of the tissue surface was shown during in vitro ablation. Dimension (diameter up to 4 mm) and time course (rise time of 100 to 300 μs) of bubble formation and tissue elevation were strikingly similar. Thus, tissue dissections are caused by the expansion of a vapor bubble within the target tissue. Coronary dissections after excimer and mid-infrared laser angioplasty might be related to the forceful bubble expansion.

Original languageEnglish (US)
Pages (from-to)1610-1618
Number of pages9
JournalJournal of the American College of Cardiology
Volume19
Issue number7
DOIs
StatePublished - 1992

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Laser Therapy
Dissection
Swine
Thulium
Lasers
Holmium
Excimer Lasers
Laser Angioplasty
Photography
Solid-State Lasers
Thoracic Aorta
Sodium Chloride
Necrosis

ASJC Scopus subject areas

  • Nursing(all)

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Origin of arterial wall dissections induced by pulsed excimer and mid-infrared laser ablation in the pig. / van Leeuwen, Ton G.; van Erven, Lieselotte; Meertens, John H.; Motamedi, Massoud; Post, Mark J.; Borst, Cornelius.

In: Journal of the American College of Cardiology, Vol. 19, No. 7, 1992, p. 1610-1618.

Research output: Contribution to journalArticle

van Leeuwen, Ton G. ; van Erven, Lieselotte ; Meertens, John H. ; Motamedi, Massoud ; Post, Mark J. ; Borst, Cornelius. / Origin of arterial wall dissections induced by pulsed excimer and mid-infrared laser ablation in the pig. In: Journal of the American College of Cardiology. 1992 ; Vol. 19, No. 7. pp. 1610-1618.
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abstract = "To study adjacent tissue damage after delivery of holmium, thulium and excimer laser pulses, porcine thoracic aortas were irradiated in vivo. After 3 days, microscopic analysis of 67 craters produced by all three lasers demonstrated large dissections extending from the craters. The mean diameter of the dissections was smaller for excimer-induced craters (1.38 ± 0.42 mm; n = 22) than for holmium-induced (2.7 ± 0.87 mm; n = 22) and thulium-induced (2.37 ± 0.42 mm; n = 14) craters (p < 0.01 vs. mid-infrared dissections). In addition, microscopic analysis demonstrated necrosis adjacent to the crater. The lateral necrotic zones of the thulium-induced craters were smaller than the holmium- and excimer-induced necrotic zones (p < 0.01). To identify the origin of the excessive tissue tearing, laser-saline and laser-tissue interaction were compared in vitro by time-resoived flash photography, in saline solution, the midinfrared lasers showed bubble formation on a microsecond time scale. The excimer laser produced similar bubbles in the vicinity of tissue. For all three lasers, elevation of the tissue surface was shown during in vitro ablation. Dimension (diameter up to 4 mm) and time course (rise time of 100 to 300 μs) of bubble formation and tissue elevation were strikingly similar. Thus, tissue dissections are caused by the expansion of a vapor bubble within the target tissue. Coronary dissections after excimer and mid-infrared laser angioplasty might be related to the forceful bubble expansion.",
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