Abstract
The recent emergence and spread of dengue hemorrhagic fever in the Americas have been a major source of concern. Efforts to control this disease are dependent on understanding the pathogenicity of dengue viruses and their transmission dynamics. Pathogenicity studies have been hampered by the lack of in vitro or in vivo models of severe dengue disease. Alternatively, molecular epidemiologic studies which associate certain dengue virus genetic types with severe dengue outbreaks may point to strains with increased pathogenicity. The comparison of nucleotide sequences (240 bp) from the E/NS1 gene region of the dengue virus genome has been shown to reflect evolutionary relationships and geographic origins of dengue virus strains. This approach was used to demonstrate an association between the introduction of two distinct genotypes of dengue type 2 virus and the appearance of dengue hemorrhagic fever in the Americas. Phylogenetic analyses suggest that these genotypes originated in Southeast Asia and that they displaced the native, American genotype in at least four countries. Vaccination and other control efforts should therefore be directed at decreasing the transmission of these 'virulent' genotypes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 244-251 |
| Number of pages | 8 |
| Journal | Virology |
| Volume | 230 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 14 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Virology
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Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. / Rico-Hesse, Rebeca; Harrison, Lisa M.; Salas, Rosa Alba; Tovar, Duilia; Nisalak, Ananda; Ramos, Celso; Boshell, Jorge; De Mesa, Maria Teresa R.; Nogueira, Rita M.R.; Rosa, Amélia Travassos Da.
In: Virology, Vol. 230, No. 2, 14.04.1997, p. 244-251.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas
AU - Rico-Hesse, Rebeca
AU - Harrison, Lisa M.
AU - Salas, Rosa Alba
AU - Tovar, Duilia
AU - Nisalak, Ananda
AU - Ramos, Celso
AU - Boshell, Jorge
AU - De Mesa, Maria Teresa R.
AU - Nogueira, Rita M.R.
AU - Rosa, Amélia Travassos Da
PY - 1997/4/14
Y1 - 1997/4/14
N2 - The recent emergence and spread of dengue hemorrhagic fever in the Americas have been a major source of concern. Efforts to control this disease are dependent on understanding the pathogenicity of dengue viruses and their transmission dynamics. Pathogenicity studies have been hampered by the lack of in vitro or in vivo models of severe dengue disease. Alternatively, molecular epidemiologic studies which associate certain dengue virus genetic types with severe dengue outbreaks may point to strains with increased pathogenicity. The comparison of nucleotide sequences (240 bp) from the E/NS1 gene region of the dengue virus genome has been shown to reflect evolutionary relationships and geographic origins of dengue virus strains. This approach was used to demonstrate an association between the introduction of two distinct genotypes of dengue type 2 virus and the appearance of dengue hemorrhagic fever in the Americas. Phylogenetic analyses suggest that these genotypes originated in Southeast Asia and that they displaced the native, American genotype in at least four countries. Vaccination and other control efforts should therefore be directed at decreasing the transmission of these 'virulent' genotypes.
AB - The recent emergence and spread of dengue hemorrhagic fever in the Americas have been a major source of concern. Efforts to control this disease are dependent on understanding the pathogenicity of dengue viruses and their transmission dynamics. Pathogenicity studies have been hampered by the lack of in vitro or in vivo models of severe dengue disease. Alternatively, molecular epidemiologic studies which associate certain dengue virus genetic types with severe dengue outbreaks may point to strains with increased pathogenicity. The comparison of nucleotide sequences (240 bp) from the E/NS1 gene region of the dengue virus genome has been shown to reflect evolutionary relationships and geographic origins of dengue virus strains. This approach was used to demonstrate an association between the introduction of two distinct genotypes of dengue type 2 virus and the appearance of dengue hemorrhagic fever in the Americas. Phylogenetic analyses suggest that these genotypes originated in Southeast Asia and that they displaced the native, American genotype in at least four countries. Vaccination and other control efforts should therefore be directed at decreasing the transmission of these 'virulent' genotypes.
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U2 - 10.1006/viro.1997.8504
DO - 10.1006/viro.1997.8504
M3 - Article
VL - 230
SP - 244
EP - 251
JO - Virology
JF - Virology
SN - 0042-6822
IS - 2
ER -