Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas

Rebeca Rico-Hesse, Lisa M. Harrison, Rosa Alba Salas, Duilia Tovar, Ananda Nisalak, Celso Ramos, Jorge Boshell, Maria Teresa R. De Mesa, Rita M.R. Nogueira, Amélia Travassos Da Rosa

Research output: Contribution to journalArticle

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Abstract

The recent emergence and spread of dengue hemorrhagic fever in the Americas have been a major source of concern. Efforts to control this disease are dependent on understanding the pathogenicity of dengue viruses and their transmission dynamics. Pathogenicity studies have been hampered by the lack of in vitro or in vivo models of severe dengue disease. Alternatively, molecular epidemiologic studies which associate certain dengue virus genetic types with severe dengue outbreaks may point to strains with increased pathogenicity. The comparison of nucleotide sequences (240 bp) from the E/NS1 gene region of the dengue virus genome has been shown to reflect evolutionary relationships and geographic origins of dengue virus strains. This approach was used to demonstrate an association between the introduction of two distinct genotypes of dengue type 2 virus and the appearance of dengue hemorrhagic fever in the Americas. Phylogenetic analyses suggest that these genotypes originated in Southeast Asia and that they displaced the native, American genotype in at least four countries. Vaccination and other control efforts should therefore be directed at decreasing the transmission of these 'virulent' genotypes.

Original languageEnglish (US)
Pages (from-to)244-251
Number of pages8
JournalVirology
Volume230
Issue number2
DOIs
StatePublished - Apr 14 1997
Externally publishedYes

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Dengue Virus
Severe Dengue
Virulence
Genotype
Southeastern Asia
North American Indians
Disease Outbreaks
Epidemiologic Studies
Vaccination
Genome
Genes

ASJC Scopus subject areas

  • Virology

Cite this

Rico-Hesse, R., Harrison, L. M., Salas, R. A., Tovar, D., Nisalak, A., Ramos, C., ... Rosa, A. T. D. (1997). Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology, 230(2), 244-251. https://doi.org/10.1006/viro.1997.8504

Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. / Rico-Hesse, Rebeca; Harrison, Lisa M.; Salas, Rosa Alba; Tovar, Duilia; Nisalak, Ananda; Ramos, Celso; Boshell, Jorge; De Mesa, Maria Teresa R.; Nogueira, Rita M.R.; Rosa, Amélia Travassos Da.

In: Virology, Vol. 230, No. 2, 14.04.1997, p. 244-251.

Research output: Contribution to journalArticle

Rico-Hesse, R, Harrison, LM, Salas, RA, Tovar, D, Nisalak, A, Ramos, C, Boshell, J, De Mesa, MTR, Nogueira, RMR & Rosa, ATD 1997, 'Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas', Virology, vol. 230, no. 2, pp. 244-251. https://doi.org/10.1006/viro.1997.8504
Rico-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C et al. Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology. 1997 Apr 14;230(2):244-251. https://doi.org/10.1006/viro.1997.8504
Rico-Hesse, Rebeca ; Harrison, Lisa M. ; Salas, Rosa Alba ; Tovar, Duilia ; Nisalak, Ananda ; Ramos, Celso ; Boshell, Jorge ; De Mesa, Maria Teresa R. ; Nogueira, Rita M.R. ; Rosa, Amélia Travassos Da. / Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. In: Virology. 1997 ; Vol. 230, No. 2. pp. 244-251.
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