Oropouche virus: Clinical, epidemiological, and molecular aspects of a neglected orthobunyavirus

Jorge Fernando Travassos Da Rosa, William Marciel De Souza, Francisco De Paula Pinheiro, Mário Luiz Figueiredo, Jedson Ferreira Cardoso, Gustavo Olszanski Acrani, Márcio Roberto Teixeira Nunes

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

Oropouche virus (OROV) is an important cause of arboviral illness in Latin American countries, more specifically in the Amazon region of Brazil, Venezuela and Peru, as well as in other countries such as Panama. In the past decades, the clinical, epidemiological, pathological, and molecular aspects of OROV have been published and provide the basis for a better understanding of this important human pathogen. Here, we describe the milestones in a comprehensive review of OROV epidemiology, pathogenesis, and molecular biology, including a description of the first isolation of the virus, the outbreaks during the past six decades, clinical aspects of OROV infection, diagnostic methods, genome and genetic traits, evolution, and viral dispersal.

Original languageEnglish (US)
Pages (from-to)1019-1030
Number of pages12
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume96
Issue number5
DOIs
StatePublished - 2017
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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