Osmolytes resist against harsh osmolarity: Something old something new

Seyed Mahdi Hosseiniyan Khatibi, Fatemeh Zununi Vahed, Simin Sharifi, Mohammadreza Ardalan, Mohammadali Mohajel Shoja, Sepideh Zununi Vahed

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

From the halophilic bacteria to human, cells have to survive under the stresses of harsh environments. Hyperosmotic stress is a process that triggers cell shrinkage, oxidative stress, DNA damage, and apoptosis and it potentially contributes to a number of human diseases. Remarkably, by high salts and organic solutes concentrations, a variety of organisms struggle with these conditions. Different strategies have been developed for cellular osmotic adaptations among which organic osmolyte synthesis/accumulation is a conserved once. Osmolytes are naturally occurring solutes used by cells of several halophilic (micro) organisms to preserve cell volume and function. In this review, the osmolytes diversity and their protective roles in harsh hyperosmolar environments from bacteria to human cells are highlighted. Moreover, it provides a close look at mammalian kidney osmoregulation at a molecular level. This review provides a concise view on the recent developments and advancements on the applications of osmolytes. Identification of disease-related osmolytes and their targeted-delivery may be used as a therapeutic measurement for treatment of the pathological conditions and the inherited diseases related to protein misfolding and aggregation. The molecular and cellular aspects of cell adaptation against harsh environmental osmolarity will benefit the development of effective drugs for many diseases.

Original languageEnglish (US)
Pages (from-to)156-164
Number of pages9
JournalBiochimie
Volume158
DOIs
StatePublished - Mar 1 2019

Fingerprint

Osmolar Concentration
Bacteria
Oxidative stress
Osmoregulation
Synthetic Chemistry Techniques
Cell Size
Agglomeration
Salts
Cells
DNA Damage
Apoptosis
Oxidative Stress
DNA
Kidney
Pharmaceutical Preparations
Proteins
Therapeutics

Keywords

  • Compatible solutes
  • Osmoadaptation
  • Protein aggregation
  • Renal cells
  • TonEBP/NFAT5

ASJC Scopus subject areas

  • Biochemistry

Cite this

Hosseiniyan Khatibi, S. M., Zununi Vahed, F., Sharifi, S., Ardalan, M., Mohajel Shoja, M., & Zununi Vahed, S. (2019). Osmolytes resist against harsh osmolarity: Something old something new. Biochimie, 158, 156-164. https://doi.org/10.1016/j.biochi.2019.01.002

Osmolytes resist against harsh osmolarity : Something old something new. / Hosseiniyan Khatibi, Seyed Mahdi; Zununi Vahed, Fatemeh; Sharifi, Simin; Ardalan, Mohammadreza; Mohajel Shoja, Mohammadali; Zununi Vahed, Sepideh.

In: Biochimie, Vol. 158, 01.03.2019, p. 156-164.

Research output: Contribution to journalReview article

Hosseiniyan Khatibi, SM, Zununi Vahed, F, Sharifi, S, Ardalan, M, Mohajel Shoja, M & Zununi Vahed, S 2019, 'Osmolytes resist against harsh osmolarity: Something old something new', Biochimie, vol. 158, pp. 156-164. https://doi.org/10.1016/j.biochi.2019.01.002
Hosseiniyan Khatibi SM, Zununi Vahed F, Sharifi S, Ardalan M, Mohajel Shoja M, Zununi Vahed S. Osmolytes resist against harsh osmolarity: Something old something new. Biochimie. 2019 Mar 1;158:156-164. https://doi.org/10.1016/j.biochi.2019.01.002
Hosseiniyan Khatibi, Seyed Mahdi ; Zununi Vahed, Fatemeh ; Sharifi, Simin ; Ardalan, Mohammadreza ; Mohajel Shoja, Mohammadali ; Zununi Vahed, Sepideh. / Osmolytes resist against harsh osmolarity : Something old something new. In: Biochimie. 2019 ; Vol. 158. pp. 156-164.
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