Osmophobics and hydrophobics: The changing landscape of protein folding

Matthew Auton, Bernard Pettitt

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We discuss recent experiments and theories concerning protein col lapse and folding. Experiments using multicomponent solutions have revealed much about the mechanism of folding. Simulation and theory have been used to interpret thermodynamic and fluorescence correlation spectroscopy experi mental results. We consider the theoretical arguments using variations of the free energy with respect to fluctuations in number and composition to consider recent experiments. We find new measures of protein stability tendencies offer a different view than the often poorly defined hydrophobic effect.

Original languageEnglish (US)
Title of host publicationFluctuation Theory of Solutions
Subtitle of host publicationApplications in Chemistry, Chemical Engineering, and Biophysics
PublisherCRC Press
Pages309-323
Number of pages15
ISBN (Electronic)9781439899236
ISBN (Print)9781439899229
StatePublished - Apr 19 2016

Fingerprint

Protein folding
Protein Stability
Fluorescence Spectrometry
Protein Folding
Thermodynamics
folding
proteins
tendencies
Proteins
Experiments
free energy
fluorescence
thermodynamics
Free energy
Fluorescence
Spectroscopy
spectroscopy
simulation
Chemical analysis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)
  • Chemistry(all)

Cite this

Auton, M., & Pettitt, B. (2016). Osmophobics and hydrophobics: The changing landscape of protein folding. In Fluctuation Theory of Solutions: Applications in Chemistry, Chemical Engineering, and Biophysics (pp. 309-323). CRC Press.

Osmophobics and hydrophobics : The changing landscape of protein folding. / Auton, Matthew; Pettitt, Bernard.

Fluctuation Theory of Solutions: Applications in Chemistry, Chemical Engineering, and Biophysics. CRC Press, 2016. p. 309-323.

Research output: Chapter in Book/Report/Conference proceedingChapter

Auton, M & Pettitt, B 2016, Osmophobics and hydrophobics: The changing landscape of protein folding. in Fluctuation Theory of Solutions: Applications in Chemistry, Chemical Engineering, and Biophysics. CRC Press, pp. 309-323.
Auton M, Pettitt B. Osmophobics and hydrophobics: The changing landscape of protein folding. In Fluctuation Theory of Solutions: Applications in Chemistry, Chemical Engineering, and Biophysics. CRC Press. 2016. p. 309-323
Auton, Matthew ; Pettitt, Bernard. / Osmophobics and hydrophobics : The changing landscape of protein folding. Fluctuation Theory of Solutions: Applications in Chemistry, Chemical Engineering, and Biophysics. CRC Press, 2016. pp. 309-323
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