Osteofibrous dysplasia and adamantinoma: A summary of diagnostic challenges and surgical techniques

Marc El Beaino, Wei Lien Wang, Sami F. Alaraj, Zbigniew Gugala, Patrick P. Lin

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Osteofibrous dysplasia is an indolent benign fibro-osseous tumor, while adamantinoma is a locally aggressive biphasic malignancy with epithelial and fibro-osseous components. Predominantly arising in the tibial diaphysis of children and young adults, both tumors are resistant to chemotherapy and radiation. Wide surgical resection is regarded as the mainstay of therapy for adamantinoma, and limb-salvage reconstructive procedures can achieve good functional outcomes, albeit with non-negligible rates of complications. This review discusses emerging advances in the pathogenesis, histogenesis, and diagnosis of these entities and presents advantages and limitations of the most common surgical techniques used for their management.

Original languageEnglish (US)
Article number101626
JournalSurgical oncology
Volume38
DOIs
StatePublished - Sep 2021

Keywords

  • Adamantinoma
  • Limb-salvage surgery
  • Orthopaedic oncology
  • Osteofibrous dysplasia
  • Surgical reconstruction

ASJC Scopus subject areas

  • Surgery
  • Oncology

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