Osteoformin Accelerates Fresh Fracture Healing in Rats

Lian Xiang Bi, Elgene G. Mainous, YaPing Zeng, William L. Buford

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Purpose: Negatively charged resins have been shown to stimulate bone repair. In previous studies, the negatively charged polypeptide polyaspartate, which has been named Osteoformin, has been shown to stimulate osteoblast differentiation in vitro. The objective of the current study was to investigate the potential effect of Osteoformin on experimental femoral fracture healing in vivo. Materials and Methods: Thirty-six male Sprague-Dawley rats were used. The femurs of anesthetized rats were stabilized with intramedullary pins and subjected to closed midshaft transverse facture by bending to failure. In experimental rats, fracture sites were injected with 100 μg of Osteoformin dissolved in 0.1 mL phosphate buffered saline (PBS) at day 1 and day 7 after surgery; in controls groups, fracture sites received 0.1 mL PBS at the intervals indicated above. Between 2 and 4 weeks after fracture, the animals were sacrificed and the healing femurs were removed for radiographic and histologic analysis. Results: Osteoformin decreased the healing time of fresh fractures in rats, as indicated by histologic and radiographic assessments. Conclusion: The results of this study show that Osteoformin improves femoral fracture healing in rats.

    Original languageEnglish (US)
    Pages (from-to)2470-2474
    Number of pages5
    JournalJournal of Oral and Maxillofacial Surgery
    Volume65
    Issue number12
    DOIs
    StatePublished - Dec 2007

    Fingerprint

    Fracture Healing
    Femoral Fractures
    Femur
    Phosphates
    Osteoblasts
    Sprague Dawley Rats
    polyaspartate
    Bone and Bones
    Control Groups
    Peptides

    ASJC Scopus subject areas

    • Dentistry(all)
    • Surgery

    Cite this

    Osteoformin Accelerates Fresh Fracture Healing in Rats. / Bi, Lian Xiang; Mainous, Elgene G.; Zeng, YaPing; Buford, William L.

    In: Journal of Oral and Maxillofacial Surgery, Vol. 65, No. 12, 12.2007, p. 2470-2474.

    Research output: Contribution to journalArticle

    Bi, Lian Xiang ; Mainous, Elgene G. ; Zeng, YaPing ; Buford, William L. / Osteoformin Accelerates Fresh Fracture Healing in Rats. In: Journal of Oral and Maxillofacial Surgery. 2007 ; Vol. 65, No. 12. pp. 2470-2474.
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    AU - Zeng, YaPing

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