Outbreak of febrile respiratory illness associated with human adenovirus type 14p1 in Gansu Province, China

Guohong Huang, Deshan Yu, Zhen Zhu, Hai Zhao, Peng Wang, Gregory C. Gray, Lei Meng, Wenbo Xu

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Objectives: Human adenovirus (HAdV) type 14 had been infrequently associated with outbreaks of febrile respiratory illness (FRI) until the HAdV-14p1 emerged in 2006 and rapidly spread in the United States. Here, we report an outbreak of FRI caused by HadV-14p1 that occurred in 2011 at a primary and middle school in China. Design: The basic information of the outbreak was recored; throat swabs were collected from 17 patients, polymerase chain reaction, A549 cell culture, and sequencing were used to identify the pathogen of the outbreak. Results: Total of 43 students were infected in this outbreak. Boys were more than girls. We identified 11 HAdV-positive specimens and 6 HAdV isolates. Genetic analysis showed that the complete hexon, fiber, and E1A sequences of isolates were nearly 100% identical with other HAdV-14p1 sequences deposited in GenBank. Conclusions: HadV-14p1 has caused outbreaks of pneumonia and mortality among adults in the United States and Europe. It may cause similar conditions among Chinese adults due to poor hygiene and sanitation. It seems prudent for China to develop a national surveillance system to determine the etiology of severe respiratory diseases and deaths among adults and school-aged children.

Original languageEnglish (US)
Pages (from-to)1048-1054
Number of pages7
JournalInfluenza and other respiratory viruses
Issue number6
StatePublished - Nov 2013
Externally publishedYes


  • Adenovirus
  • Epidemiology
  • Respiratory tract infections

ASJC Scopus subject areas

  • Epidemiology
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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