Outbreak of vancomycin-resistant enterococci in a burn unit

P. S. Falk, J. Winnike, C. Woodmansee, M. Desai, C. G. Mayhall

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

OBJECTIVE: To investigate and control an outbreak of colonization and infection caused by vancomycin-resistant enterococci (VRE) in a burn intensive care unit (BICU). DESIGN: Epidemiological investigation, including multiple point-prevalence culture surveys of patients and environment, cultures from hands of healthcare workers (HCWs), pulsed-field gel electrophoresis (PFGE) typing of patient and environmental isolates, case-control study, and institution and monitoring of control measures. SETTING: BICU in an 800-bed university medical center in Galveston, Texas. RESULTS: Between June 6, 1996, and July 14, 1997, 21 patients were colonized by VRE, and 4 of these patients developed bacteremia. Of 2,844 environmental cultures, 338 (11.9%) were positive, but all hand cultures from HCWs were negative. PFGE typing indicated that the outbreak was clonal, with VRE isolates from patients differing by ≤4 bands from the index case. Thirteen of 14 environmental isolates varied by ≤4 bands from the pattern of the index case. A case-control study analyzed by exact logistic regression identified diarrhea (odds ratio [OR], 43.9; 95% confidence interval [CI95], 5.5-infinity; P=.0001) and administration of an antacid (OR, 24.2; CI95, 2.9-infinity: P=.002) as independent risk factors for acquisition of VRE. During a 5-week period in October and November 1996, all patient and 317 environmental cultures were negative for VRE. The outbreak recurred from a contaminated electrocardiogram lead that had not been identified during the prior 5 weeks. VRE were finally eradicated from the BICU in July 1997, using barrier isolation and a very aggressive environmental decontamination program. CONCLUSIONS: A VRE outbreak in a BICU over 13 months was caused by a single clone. After apparent eradication of VRE from a BICU, recrudescence of the outbreak occurred, evidently from a small inapparent source of environmental contamination. Changes in gastrointestinal (GI) tract function (motility) and administration of medications, other than antibiotics, that have an effect on the GI tract may increase the risk of GI tract colonization by VRE in burn patients. Application of barrier isolation and an aggressive environmental decontamination program can eradicate VRE from a burn population.

Original languageEnglish (US)
Pages (from-to)575-582
Number of pages8
JournalInfection Control and Hospital Epidemiology
Volume21
Issue number9
StatePublished - 2000

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Burn Units
Disease Outbreaks
Intensive Care Units
Gastrointestinal Tract
Decontamination
Pulsed Field Gel Electrophoresis
Case-Control Studies
Hand
Odds Ratio
Vancomycin-Resistant Enterococci
Delivery of Health Care
Antacids
Bacteremia
Diarrhea
Electrocardiography
Clone Cells
Logistic Models
Confidence Intervals
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)

Cite this

Falk, P. S., Winnike, J., Woodmansee, C., Desai, M., & Mayhall, C. G. (2000). Outbreak of vancomycin-resistant enterococci in a burn unit. Infection Control and Hospital Epidemiology, 21(9), 575-582.

Outbreak of vancomycin-resistant enterococci in a burn unit. / Falk, P. S.; Winnike, J.; Woodmansee, C.; Desai, M.; Mayhall, C. G.

In: Infection Control and Hospital Epidemiology, Vol. 21, No. 9, 2000, p. 575-582.

Research output: Contribution to journalArticle

Falk, PS, Winnike, J, Woodmansee, C, Desai, M & Mayhall, CG 2000, 'Outbreak of vancomycin-resistant enterococci in a burn unit', Infection Control and Hospital Epidemiology, vol. 21, no. 9, pp. 575-582.
Falk PS, Winnike J, Woodmansee C, Desai M, Mayhall CG. Outbreak of vancomycin-resistant enterococci in a burn unit. Infection Control and Hospital Epidemiology. 2000;21(9):575-582.
Falk, P. S. ; Winnike, J. ; Woodmansee, C. ; Desai, M. ; Mayhall, C. G. / Outbreak of vancomycin-resistant enterococci in a burn unit. In: Infection Control and Hospital Epidemiology. 2000 ; Vol. 21, No. 9. pp. 575-582.
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