Outcome of renal transplant in hereditary gelsolin amyloidosis

Mohammadali M. Shoja, Mohammad R. Ardalan, R. Shane Tubbs, Sari Kiuru-Enari

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Amyloid nephropathy is an unusual manifestation of hereditary gelsolin amyloidosis and may present with proteinuria and progressive renal failure. We report the first case of renal transplantation in a patient with hereditary gelsolin amyloidosis complicated by end-stage renal disease. The patient was a 44-year-old man from the Northwest of Iran who had undergone hemodialysis for 1 year. He finally received a living, unrelated renal transplant. During a 6-year posttransplant period, the patient maintained stable allograft function without proteinuria. No significant infectious or cardiac complications were noted. Although a definite conclusion cannot be reached with a single case, this report may indicate that renal transplantation can be successfully attempted in patients with hereditary gelsolin amyloidosis and amyloid nephropathy. Renal transplantation has been performed in various hereditary, primary, and secondary amyloidoses. A brief review of this topic is presented.

Original languageEnglish (US)
Pages (from-to)370-372
Number of pages3
JournalAmerican Journal of the Medical Sciences
Issue number5
StatePublished - May 2009
Externally publishedYes


  • Hereditary gelsolin amyloidosis
  • Kidney
  • Nephropathy
  • Transplant

ASJC Scopus subject areas

  • General Medicine


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