Outcomes of liver transplantation alone after listing for simultaneous kidney: Comparison to simultaneous liver kidney transplantation

Bashar Hmoud, Yong Fang Kuo, Russell H. Wiesner, Ashwani K. Singal

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19 Citations (Scopus)

Abstract

Data on patient and liver graft survival comparing liver transplantation alone after listing for kidney with simultaneous liver kidney (SLK) transplantation are scanty. Methods. United Network Organ Sharing network database (1994-2011) queried for liver transplantation alone after being listed for kidney and SLK transplants. Results. Of 65,206 first liver transplants, 3549 were listed for simultaneous kidney. Of these, 422 (12%) received only liver (LIST) and differed from SLK recipients for the white race (64% vs. 57%; 0.005), diabetes (27% vs. 37%; P = 0.02), model for end-stage liver disease era (68% vs. 82%; P = 0.0001), serum creatinine (2.9±1.9 vs. 4.3±2.5; P < 0.0001), dialysis (35% vs. 64%; P < 0.0001), and donor risk index (1.6±0.4 vs. 1.5±0.3; P < 0.0001). Overall survival was poorer in the LIST group (55% vs. 76%; P < 0.0001). A higher proportion of patients died within 2 days of transplantation in LIST group (11%vs. 0.5%; P < 0.0001),mostly fromcardiovascular causes. After excluding these patients, odds of patient mortality and liver graft loss were about 1.2-fold and twofold higher in the LIST group. A total of 103 (24%) patients needed a renal transplantation in the LIST group with 16 (4%) receiving kidney within first year after transplantation. After excluding patients receiving kidney within first year, about 33% recovered renal function to above estimated GFR of greater than 60 mL per min. Conclusion. Guidelines are needed for patient selection to list for and receipt of simultaneous liver kidney transplantation.

Original languageEnglish (US)
Pages (from-to)823-828
Number of pages6
JournalTransplantation
Volume99
Issue number4
DOIs
StatePublished - Apr 1 2015

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Liver Transplantation
Kidney Transplantation
Kidney
Liver
Transplants
Transplantation
End Stage Liver Disease
Graft Survival
Patient Selection
Dialysis
Creatinine
Tissue Donors
Databases
Guidelines
Survival
Mortality
Serum

ASJC Scopus subject areas

  • Transplantation
  • Medicine(all)

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Outcomes of liver transplantation alone after listing for simultaneous kidney : Comparison to simultaneous liver kidney transplantation. / Hmoud, Bashar; Kuo, Yong Fang; Wiesner, Russell H.; Singal, Ashwani K.

In: Transplantation, Vol. 99, No. 4, 01.04.2015, p. 823-828.

Research output: Contribution to journalArticle

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abstract = "Data on patient and liver graft survival comparing liver transplantation alone after listing for kidney with simultaneous liver kidney (SLK) transplantation are scanty. Methods. United Network Organ Sharing network database (1994-2011) queried for liver transplantation alone after being listed for kidney and SLK transplants. Results. Of 65,206 first liver transplants, 3549 were listed for simultaneous kidney. Of these, 422 (12{\%}) received only liver (LIST) and differed from SLK recipients for the white race (64{\%} vs. 57{\%}; 0.005), diabetes (27{\%} vs. 37{\%}; P = 0.02), model for end-stage liver disease era (68{\%} vs. 82{\%}; P = 0.0001), serum creatinine (2.9±1.9 vs. 4.3±2.5; P < 0.0001), dialysis (35{\%} vs. 64{\%}; P < 0.0001), and donor risk index (1.6±0.4 vs. 1.5±0.3; P < 0.0001). Overall survival was poorer in the LIST group (55{\%} vs. 76{\%}; P < 0.0001). A higher proportion of patients died within 2 days of transplantation in LIST group (11{\%}vs. 0.5{\%}; P < 0.0001),mostly fromcardiovascular causes. After excluding these patients, odds of patient mortality and liver graft loss were about 1.2-fold and twofold higher in the LIST group. A total of 103 (24{\%}) patients needed a renal transplantation in the LIST group with 16 (4{\%}) receiving kidney within first year after transplantation. After excluding patients receiving kidney within first year, about 33{\%} recovered renal function to above estimated GFR of greater than 60 mL per min. Conclusion. Guidelines are needed for patient selection to list for and receipt of simultaneous liver kidney transplantation.",
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