TY - JOUR
T1 - Outcomes of patients with COPD hospitalized for coronavirus disease 2019
AU - Puebla Neira, Daniel A.
AU - Watts, Abigail
AU - Seashore, Justin
AU - Duarte, Alexander
AU - Nishi, Shawn P.
AU - Polychronopoulou, Efstathia
AU - Kuo, Yong Fang
AU - Baillargeon, Jacques
AU - Sharma, Gulshan
N1 - Funding Information:
Drs. Puebla Neira, Watts, Seashore, Duarte, Nishi, Baillargeon and Sharma, along with Ms. Polychronopoulou, have nothing to disclose. Dr. Kuo reports grants from the UTMB Claude D. Pepper Older Americans Independence Center and from the Agency of Healthcare Research and Quality during the conduct of the study.
Funding Information:
Abbreviations: chronic obstructive pulmonary disease, COPD; coronavirus disease 2019, COVID-19; odds ratio, OR; confidence interval, CI, severe acute respiratory syndrome coronavirus 2, SARS-CoV-2; electronic health record, EHR; International Classification for Diseases, 10th revision, Clinical Modification, ICD-10-CM; body mass index, BMI; chronic kidney disease, CKD; end-stage renal disease, ESRD; congestive heart failure, CHF; coronary artery disease, CAD; inhaled corticosteroid, ICS Funding Support: Dr. Kuo reports grants from the University of Texas Medical Branch Claude D. Pepper Older Americans Independence Center and from the Agency of Healthcare Research and Quality during the conduct of the study. Date of Acceptance: September 27, 2021 | Published Online Date: October 5, 2021 Citation: Puebla Neira DA, Watts A, Seashore J, et al. Outcomes of patients with COPD hospitalized for coronavirus disease 2019. Chronic Obstr Pulm Dis. 2021;8(4):517-527. doi: https://doi.org/10.15326/jcopdf.2021.0245
Funding Information:
The authors acknowledge and greatly appreciate the assistance in the preparation of this manuscript by: En Shuo Hsu, MA (Office of Biostatistics, University of Texas Medical Branch, Galveston, Texas); Sarah Toombs Smith, PhD, ELS (Research Communications Manager and Fellow, Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas); Tara N. Atkins, MLIS (Reference Librarian Moody Medical Library/Academic Resources, University of Texas Medical Branch, Galveston, Texas).
Publisher Copyright:
© 2021 COPD Foundation. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Rationale: There is controversy concerning the association of chronic obstructive pulmonary disease (COPD) as an independent risk factor for mortality in patients hospitalized with coronavirus disease 2019 (COVID-19). We hypothesize that patients with COPD hospitalized for COVID-19 have increased mortality risk. Objective: To assess whether COPD increased the risk of mortality among patients hospitalized for COVID-19. Methods: We conducted a retrospective cohort analysis of patients with COVID-19 between February 10, 2020, and November 10, 2020, and hospitalized within 14 days of diagnosis. Electronic health records from U.S. facilities (Optum COVID-19 data) were used. Results: In our cohort of 31,526 patients, 3030 (9.6%) died during hospitalization. Mortality in patients with COPD was higher than that of patients without COPD, 14.02% and 8.8%, respectively. Univariate (odds ratio [OR] 1.68; 95% confidence interval [CI] 1.54 to1.84) and multivariate (OR 1.33; 95% CI 1.18 to1.50) analysis showed that patients with COPD had greater odds of death due to COVID-19 than patients without COPD. We found significant interactions between COPD and sex and COPD and age. Specifically, the increased mortality risk associated with COPD was observed among female (OR 1.62; 95% CI 1.36 to 1.95) but not male patients (OR 1.14; 95% CI 0.97 to 1.34); and in patients aged 40 to 64 (OR 1.42; 95% CI 1.07 to 1.90) and 65 to 79 (OR 1.48; 95% CI 1.23 to 1.78) years. Conclusions: COPD is an independent risk factor for death in adults aged 40 to 79 years hospitalized with COVID-19 infection.
AB - Rationale: There is controversy concerning the association of chronic obstructive pulmonary disease (COPD) as an independent risk factor for mortality in patients hospitalized with coronavirus disease 2019 (COVID-19). We hypothesize that patients with COPD hospitalized for COVID-19 have increased mortality risk. Objective: To assess whether COPD increased the risk of mortality among patients hospitalized for COVID-19. Methods: We conducted a retrospective cohort analysis of patients with COVID-19 between February 10, 2020, and November 10, 2020, and hospitalized within 14 days of diagnosis. Electronic health records from U.S. facilities (Optum COVID-19 data) were used. Results: In our cohort of 31,526 patients, 3030 (9.6%) died during hospitalization. Mortality in patients with COPD was higher than that of patients without COPD, 14.02% and 8.8%, respectively. Univariate (odds ratio [OR] 1.68; 95% confidence interval [CI] 1.54 to1.84) and multivariate (OR 1.33; 95% CI 1.18 to1.50) analysis showed that patients with COPD had greater odds of death due to COVID-19 than patients without COPD. We found significant interactions between COPD and sex and COPD and age. Specifically, the increased mortality risk associated with COPD was observed among female (OR 1.62; 95% CI 1.36 to 1.95) but not male patients (OR 1.14; 95% CI 0.97 to 1.34); and in patients aged 40 to 64 (OR 1.42; 95% CI 1.07 to 1.90) and 65 to 79 (OR 1.48; 95% CI 1.23 to 1.78) years. Conclusions: COPD is an independent risk factor for death in adults aged 40 to 79 years hospitalized with COVID-19 infection.
KW - Chronic obstructive pulmonary disease
KW - COPD
KW - COVID-19
KW - Mortality
UR - http://www.scopus.com/inward/record.url?scp=85119500836&partnerID=8YFLogxK
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U2 - 10.15326/JCOPDF.2021.0245
DO - 10.15326/JCOPDF.2021.0245
M3 - Article
AN - SCOPUS:85119500836
VL - 8
SP - 517
EP - 527
JO - Chronic Obstructive Pulmonary Diseases
JF - Chronic Obstructive Pulmonary Diseases
SN - 2372-952X
IS - 4
ER -