Outer membrane permeability of Actinobacter calcoaceticus mediates susceptibility to rat polymorphonuclear leukocyte granule contents

M. J. Loeffelholz, M. C. Modrzakowski

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Growth of Acinetobacter calcoaceticus on specific alkanes altered the outer membrane permeability of the organism, as indicated by a change in sensitivity to the antibiotic actinomycin D. As the carbon length of the alkane energy source decreased, outer membrane permeability and susceptibility to actinomycin D increased. Concomitant with the increase in outer membrane permeability, A. calcoaceticus became more susceptible to the oxygen-independent antimicrobial activity of extracted contents from rat polymorphonuclear leukocyte granules. Individual fractions of granule extract possessed no antimicrobial activity against A. calcoaceticus. The alkane-induced change in outer membrane permeability was not associated with alterations of lipopolysaccharide O antigen. An outer membrane permeability mechanism, independent of changes in lipopolysaccharide content, mediating susceptibility to the oxygen-independent antimicrobial activity of rat polymorphonuclear leukocyte granule contents is suggested.

Original languageEnglish
Pages (from-to)2296-2299
Number of pages4
JournalInfection and Immunity
Volume55
Issue number9
StatePublished - 1987
Externally publishedYes

Fingerprint

Acinetobacter calcoaceticus
Permeability
Neutrophils
Alkanes
Membranes
Dactinomycin
Lipopolysaccharides
Oxygen
O Antigens
Carbon
Anti-Bacterial Agents
Growth

ASJC Scopus subject areas

  • Immunology

Cite this

Outer membrane permeability of Actinobacter calcoaceticus mediates susceptibility to rat polymorphonuclear leukocyte granule contents. / Loeffelholz, M. J.; Modrzakowski, M. C.

In: Infection and Immunity, Vol. 55, No. 9, 1987, p. 2296-2299.

Research output: Contribution to journalArticle

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