John E. Wiktorowicz

    Research output: Contribution to journalArticlepeer-review


    Although broadly defined in the literature, for the purpose of this section, we define systems biology as the description of the dynamic genomic, proteomic, and metabolomic processes integrated into a functional model of the cell, organelle, or tissue that is capable of accurately tracking the biological system's response to environmental perturbations. The goal of this section is to complete the tripartite description of asthma systems biology, initiated by the previous section (Section II: Genetics and Genomics of Asthma), by reviewing the recent literature-the types and methods of sample collection, processing, analysis, and instrumentation-of metabolomic and proteomic investigations, including functional proteomic studies of the asthma innate immune response and glucocorticoid (GC) receptor signaling with reference to GC resistance in severe asthma.

    Original languageEnglish (US)
    Pages (from-to)203-205
    Number of pages3
    JournalAdvances in Experimental Medicine and Biology
    StatePublished - 2014


    • Airway inflammation
    • Asthma
    • Bronchoscopic microsampling
    • Broncoalveolar lavage
    • Epithelial lining fluid
    • Exhaled breath condensate
    • Induced sputum
    • Proteomics
    • Sample prep
    • Size-exclusion chromatography

    ASJC Scopus subject areas

    • General Biochemistry, Genetics and Molecular Biology
    • General Medicine


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