John E. Wiktorowicz

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Although broadly defined in the literature, for the purpose of this section, we define systems biology as the description of the dynamic genomic, proteomic, and metabolomic processes integrated into a functional model of the cell, organelle, or tissue that is capable of accurately tracking the biological system's response to environmental perturbations. The goal of this section is to complete the tripartite description of asthma systems biology, initiated by the previous section (Section II: Genetics and Genomics of Asthma), by reviewing the recent literature-the types and methods of sample collection, processing, analysis, and instrumentation-of metabolomic and proteomic investigations, including functional proteomic studies of the asthma innate immune response and glucocorticoid (GC) receptor signaling with reference to GC resistance in severe asthma.

Original languageEnglish (US)
Title of host publicationHeterogeneity in Asthma
PublisherSpringer New York LLC
Number of pages3
ISBN (Print)9781461486022
StatePublished - 2014
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


  • Airway inflammation
  • Asthma
  • Bronchoscopic microsampling
  • Broncoalveolar lavage
  • Epithelial lining fluid
  • Exhaled breath condensate
  • Induced sputum
  • Proteomics
  • Sample prep
  • Size-exclusion chromatography

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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