Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy

Eszter M. Horváth, Rita Magenheim, Nóra J. Béres, Rita Benko, Tamás Pék, Ádám G. Tabák, Csaba Szabo

    Research output: Contribution to journalArticle

    Abstract

    Background. Oxidative-nitrative stress and poly (ADP-ribose) polymerase activation have been previously observed in healthy and gestational diabetic pregnancies, and they were also linked to the development of metabolic diseases. The aim of the present study was to examine these parameters and their correlation to known metabolic risk factors following healthy and gestational diabetic pregnancies. Methods. Fasting and 2 h postload plasma total peroxide level, protein tyrosine nitration, and poly (ADP-ribose) polymerase activation were measured in circulating leukocytes three years after delivery in women following healthy, "mild" (diet-Treated) or "severe" (insulin-Treated) gestational diabetic pregnancy during a standard 75 g OGTT. Nulliparous women and men served as control groups. Results. Fasting plasma total peroxide level was significantly elevated in women with previous pregnancy (B = 0.52 ± 0.13; p<0.001), with further increase in women with insulin-Treated gestational diabetes (B=0.36±0.17; p<0.05) (R2=0.419). Its level was independently related to previous pregnancy (B=0.47±0.14; p<0.01) and current CRP levels (B=0.06±0.02; p<0.05) (R2=0.306). Conclusions. Elevated oxidative stress but not nitrative stress or poly (ADP-ribose) polymerase activation can be measured three years after pregnancy. The increased oxidative stress may reflect the cost of reproduction and possibly play a role in the increased metabolic risk observed in women with a history of severe gestational diabetes mellitus.

    Original languageEnglish (US)
    Article number1743253
    JournalOxidative Medicine and Cellular Longevity
    Volume2018
    DOIs
    StatePublished - Jan 1 2018

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    Oxidative stress
    Poly(ADP-ribose) Polymerases
    Oxidative Stress
    Chemical activation
    Peroxides
    Medical problems
    Pregnancy
    Insulin
    Nitration
    Plasmas
    Gestational Diabetes
    Nutrition
    Tyrosine
    Fasting
    Metabolic Diseases
    Glucose Tolerance Test
    Reproduction
    Costs
    Proteins
    Leukocytes

    ASJC Scopus subject areas

    • Biochemistry
    • Aging
    • Cell Biology

    Cite this

    Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy. / Horváth, Eszter M.; Magenheim, Rita; Béres, Nóra J.; Benko, Rita; Pék, Tamás; Tabák, Ádám G.; Szabo, Csaba.

    In: Oxidative Medicine and Cellular Longevity, Vol. 2018, 1743253, 01.01.2018.

    Research output: Contribution to journalArticle

    Horváth, Eszter M. ; Magenheim, Rita ; Béres, Nóra J. ; Benko, Rita ; Pék, Tamás ; Tabák, Ádám G. ; Szabo, Csaba. / Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy. In: Oxidative Medicine and Cellular Longevity. 2018 ; Vol. 2018.
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    T1 - Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy

    AU - Horváth, Eszter M.

    AU - Magenheim, Rita

    AU - Béres, Nóra J.

    AU - Benko, Rita

    AU - Pék, Tamás

    AU - Tabák, Ádám G.

    AU - Szabo, Csaba

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    N2 - Background. Oxidative-nitrative stress and poly (ADP-ribose) polymerase activation have been previously observed in healthy and gestational diabetic pregnancies, and they were also linked to the development of metabolic diseases. The aim of the present study was to examine these parameters and their correlation to known metabolic risk factors following healthy and gestational diabetic pregnancies. Methods. Fasting and 2 h postload plasma total peroxide level, protein tyrosine nitration, and poly (ADP-ribose) polymerase activation were measured in circulating leukocytes three years after delivery in women following healthy, "mild" (diet-Treated) or "severe" (insulin-Treated) gestational diabetic pregnancy during a standard 75 g OGTT. Nulliparous women and men served as control groups. Results. Fasting plasma total peroxide level was significantly elevated in women with previous pregnancy (B = 0.52 ± 0.13; p<0.001), with further increase in women with insulin-Treated gestational diabetes (B=0.36±0.17; p<0.05) (R2=0.419). Its level was independently related to previous pregnancy (B=0.47±0.14; p<0.01) and current CRP levels (B=0.06±0.02; p<0.05) (R2=0.306). Conclusions. Elevated oxidative stress but not nitrative stress or poly (ADP-ribose) polymerase activation can be measured three years after pregnancy. The increased oxidative stress may reflect the cost of reproduction and possibly play a role in the increased metabolic risk observed in women with a history of severe gestational diabetes mellitus.

    AB - Background. Oxidative-nitrative stress and poly (ADP-ribose) polymerase activation have been previously observed in healthy and gestational diabetic pregnancies, and they were also linked to the development of metabolic diseases. The aim of the present study was to examine these parameters and their correlation to known metabolic risk factors following healthy and gestational diabetic pregnancies. Methods. Fasting and 2 h postload plasma total peroxide level, protein tyrosine nitration, and poly (ADP-ribose) polymerase activation were measured in circulating leukocytes three years after delivery in women following healthy, "mild" (diet-Treated) or "severe" (insulin-Treated) gestational diabetic pregnancy during a standard 75 g OGTT. Nulliparous women and men served as control groups. Results. Fasting plasma total peroxide level was significantly elevated in women with previous pregnancy (B = 0.52 ± 0.13; p<0.001), with further increase in women with insulin-Treated gestational diabetes (B=0.36±0.17; p<0.05) (R2=0.419). Its level was independently related to previous pregnancy (B=0.47±0.14; p<0.01) and current CRP levels (B=0.06±0.02; p<0.05) (R2=0.306). Conclusions. Elevated oxidative stress but not nitrative stress or poly (ADP-ribose) polymerase activation can be measured three years after pregnancy. The increased oxidative stress may reflect the cost of reproduction and possibly play a role in the increased metabolic risk observed in women with a history of severe gestational diabetes mellitus.

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