Oxidative stress and aging: Is methylglyoxal the hidden enemy?

Kaushik M. Desai, Tuanjie Chang, Hui Wang, Ali Banigesh, Arti Dhar, Jianghai Liu, Ashley Untereiner, Lingyun Wu

Research output: Contribution to journalReview article

134 Scopus citations

Abstract

Aging is a multifactorial process that involves changes at the cellular, tissue, organ and the whole body levels resulting in decreased functioning, development of diseases, and ultimately death. Oxidative stress is believed to be a very important factor in causing aging and age-related diseases. Oxidative stress is caused by an imbalance between oxidants such as reactive oxygen species (ROS) and antioxidants. ROS are produced from the mitochondrial electron transport chain and many oxidative reactions. Methylglyoxal (MG) is a highly reactive dicarbonyl metabolite formed during glucose, protein and fatty acid metabolism. MG levels are elevated in hyperglycemia and other conditions. An excess of MG formation can increase ROS production and cause oxidative stress. MG reacts with proteins, DNA and other biomolecules, and is a major precursor of advanced glycation end products (AGEs). AGEs are also associated with the aging process and age-related diseases such as cardiovascular complications of diabetes, neurodegenerative diseases and connective tissue disorders. AGEs also increase oxidative stress. In this review we discuss the potential role of MG in the aging process through increasing oxidative stress besides causing AGEs formation. Specific and effective scavengers and crosslink breakers of MG and AGEs are being developed and can become potential treatments to slow the aging process and prevent many diseases.

Original languageEnglish (US)
Pages (from-to)273-284
Number of pages12
JournalCanadian journal of physiology and pharmacology
Volume88
Issue number3
DOIs
StatePublished - Mar 1 2010

Keywords

  • Advanced glycation end products
  • Aging
  • Methylglyoxal
  • Oxidative stress

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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  • Cite this

    Desai, K. M., Chang, T., Wang, H., Banigesh, A., Dhar, A., Liu, J., Untereiner, A., & Wu, L. (2010). Oxidative stress and aging: Is methylglyoxal the hidden enemy? Canadian journal of physiology and pharmacology, 88(3), 273-284. https://doi.org/10.1139/Y10-001