Oxidative stress and cardiac remodeling: An updated edge

Abeer M. Rababa’h, Ashley Guillory, Rima Mustafa, Tamara Hijjawi

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Background: A common phenotype associated with heart failure is the development of cardiac hypertrophy. Cardiac hypertrophy occurs in response to stress, such as hypertension, coronary vascular disease, or myocardial infarction. The most critical pathophysiological conditions involved may include dilated hypertrophy, fibrosis and contractile malfunction. The intricate pathophysiological mechanisms of cardiac hypertrophy have been the core of several scientific studies, which may help in opening a new avenue in preventive and curative procedures. Objectives: To our knowledge from the literature, the development of cardiac remodeling and hypertrophy is multifactorial. Thus, in this review, we will focus and summarize the potential role of oxidative stress in cardiac hypertrophy development. Conclusion: Oxidative stress is considered a major stimulant for the signal transduction in cardiac cells pathological conditions, including inflammatory cytokines, and MAP kinase. The understanding of the pathophysiological mechanisms which are involved in cardiac hypertrophy and remodeling process is crucial for the development of new therapeutic plans, especially that the mortality rates related to cardiac remodeling/dysfunction remain high.

Original languageEnglish (US)
Pages (from-to)53-59
Number of pages7
JournalCurrent Cardiology Reviews
Volume14
Issue number1
DOIs
StatePublished - Mar 1 2018

Fingerprint

Cardiomegaly
Oxidative Stress
Vascular Diseases
Hypertrophy
Coronary Disease
Signal Transduction
Fibrosis
Phosphotransferases
Heart Failure
Myocardial Infarction
Cytokines
Hypertension
Phenotype
Mortality

Keywords

  • Hypertrophy
  • Mitochondria
  • NAPDH
  • Protein kinase-C
  • Reactive oxygen species
  • Remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Oxidative stress and cardiac remodeling : An updated edge. / Rababa’h, Abeer M.; Guillory, Ashley; Mustafa, Rima; Hijjawi, Tamara.

In: Current Cardiology Reviews, Vol. 14, No. 1, 01.03.2018, p. 53-59.

Research output: Contribution to journalReview article

Rababa’h, AM, Guillory, A, Mustafa, R & Hijjawi, T 2018, 'Oxidative stress and cardiac remodeling: An updated edge', Current Cardiology Reviews, vol. 14, no. 1, pp. 53-59. https://doi.org/10.2174/1573403X14666180111145207
Rababa’h, Abeer M. ; Guillory, Ashley ; Mustafa, Rima ; Hijjawi, Tamara. / Oxidative stress and cardiac remodeling : An updated edge. In: Current Cardiology Reviews. 2018 ; Vol. 14, No. 1. pp. 53-59.
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